RNA
major groove modifications improve siRNA stability and biological
activity.Terrazas M, Kool ET.
Nucleic
Acids Res. 2008 Nov 2.
PMID: 19042976
siRNAの修飾
Noncoding
Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing
of Overlapping and Adjacent Genes.
Wierzbicki AT, Haag JR, Pikaard CS.
Cell. 2008 Nov
14;135(4):635-48.
PMID: 19013275
非コード領域の転写
siRecords:
a database of mammalian RNAi experiments and efficacies.
Ren Y, Gong W, Zhou H, Wang Y, Xiao F, Li T.
Nucleic
Acids Res. 2008 Nov 7.
PMID: 18996894
哺乳類のsiRNA実験のデータベース
5'-Triphosphate-siRNA:
turning gene silencing and Rig-I activation against melanoma.
Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS,
Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M,
Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers
R, Hacker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V,
Endres S, Tuting T, Hartmann G.
Nat Med.
2008 Nov;14(11):1256-63. Epub 2008 Nov 2.
PMID: 18978796
5'-3リン酸のsiRNA
Li
F, Huarte M, Zaratiegui M, Vaughn MW, Shi Y, Martienssen R, Cande WZ.
Lid2 is required for coordinating H3K4 and H3K9 methylation of
heterochromatin and euchromatin.
Cell. 2008 Oct
17;135(2):272-83.
PMID: 18957202
ヒストンのメチル化とRNAi機能への影響
Bayne
EH, Portoso M, Kagansky A, Kos-Braun IC, Urano T, Ekwall K, Alves F, Rappsilber
J, Allshire RC.
Splicing factors facilitate RNAi-directed silencing in fission
yeast.
Science. 2008 Oct 24;322(5901):602-6.
PMID: 18948543
ヘテロクロマチンの形成にRNAi機能が直接関与
Aravin
AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, Toth KF, Bestor T, Hannon
GJ.
A piRNA pathway primed by individual transposons is linked to
de novo DNA methylation in mice.
Mol
Cell. 2008 Sep 26;31(6):785-99.
PMID: 18922463
piRNAがトランスポゾンのメチル化に関与
Konig
R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, Irelan JT, Chiang CY, Tu BP, De
Jesus PD, Lilley CE, Seidel S, Opaluch AM, Caldwell JS, Weitzman MD, Kuhen KL,
Bandyopadhyay S, Ideker T, Orth AP, Miraglia LJ, Bushman FD, Young JA, Chanda
SK.
Global analysis of host-pathogen interactions that regulate
early-stage HIV-1 replication.
Cell. 2008 Oct
3;135(1):49-60.
PMID: 18854154
HIV-1の機能をsiRNAで解析
Mykhaylyk
O, Zelphati O, Rosenecker J, Plank C.
siRNA delivery by magnetofection.
Curr Opin Mol Ther.
2008 Oct;10(5):493-505.
PMID: 18830925
磁性ナノ粒子でsiRNAを導入
Abbas
T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A.
PCNA-dependent regulation of p21 ubiquitylation and degradation
via the CRL4Cdt2 ubiquitin ligase complex.
Genes
Dev. 2008 Sep 15;22(18):2496-506.
PMID: 18794347
PCNAのsiRNAでp21の分解をコントロール
Braam
SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL.
Feeder-free culture of human embryonic stem cells in
conditioned medium for efficient genetic modification.
Nat
Protoc. 2008 Aug;3(9):1435-1443.
PMID: 18772870
Kirchhoff
F.
Silencing HIV-1 In Vivo.
Cell. 2008 Aug
22; 134( 4): 566-8.
PMID: 18724929
Okamura
K, Lai EC.
Endogenous small interfering RNAs in animals.
Nat Rev Mol Cell Biol.
2008 Sep; 9( 9): 673-8.
Chemically modified siRNA: tools and applications.
Drug
Discov Today. 2008 Jul 7. [Epub ahead of print]
PMID: 18614389
da
Silva Correia J, Miranda Y, Leonard N, Ulevitch R.
SGT1 is essential for Nod1 activation.
Proc
Natl Acad Sci U S A. 2007 Apr 9; [Epub ahead of print]
PMID: 17420470
植物の抗病原系をコントロール
Choudhary
S, Lee HC, Maiti M, He Q, Cheng P, Liu Q, Liu Y.
A double-stranded RNA response program important for RNAi efficiency.
Mol Cell Biol. 2007
Mar 19; [Epub ahead of print]
PMID: 17371837
Craig
AL, Chrystal J, Fraser J, Sphyris N, Lin Y, Harrison B, Scott M, Dornreiter I,
Hupp TR.
The MDM2 Ubiquitination Signal in the DNA-Binding Domain of p53 Forms a Docking
Site for Calcium Calmodulin Kinase Superfamily Members.
Mol Cell Biol. 2007 Mar 5; [Epub
ahead of print]
PMID: 17339337
ユビキチン化リン酸化のドメイン解析
Medarova
Z, Pham W, Farrar C, Petkova V, Moore A.
In vivo imaging of siRNA delivery and silencing in tumors.
Nat Med. 2007 Feb 25; [Epub ahead
of print]
PMID: 17322898
磁石で標識するオリゴをMRIで観察
Gunawardane
LS, Saito K, Nishida KM, Miyoshi K, Kawamura Y, Nagami T, Siomi H, Siomi
MC.
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in
Drosophila.
Science. 2007 Feb 22;
[Epub ahead of print]
PMID: 17322028
rasiRNAの特徴
Proepper
C, Johannsen S, Liebau S, Dahl J, Vaida B, Bockmann J, Kreutz MR, Gundelfinger
ED, Boeckers TM.
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis
and synapse formation.
EMBO
J. 2007 Feb 15; [Epub ahead of print]
PMID: 17304222
siRNAで細胞の形態を決める
Kojima
S, Matsumoto K, Hirose M, Shimada M, Nagano M, Shigeyoshi Y, Hoshino SI, Ui-Tei
K, Saigo K, Green CB, Sakaki Y, Tei H.
LARK activates posttranscriptional expression of an essential mammalian clock
protein, PERIOD1.
Proc
Natl Acad Sci U S A. 2007 Jan 30; [Epub ahead of print]
PMID:
17264215
period遺伝子発現量をコントロールする遺伝子を見つけました
Sioud
M.
RNAi therapy: antibodies guide the way.
Gene Ther. 2006 Feb;13(3):194-5. No abstract
available.
PMID: 17243203
Dong
B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA,
Silverman RH.
An infectious retrovirus susceptible to an IFN antiviral pathway from human
prostate tumors.
Proc
Natl Acad Sci U S A. 2007 Jan 18; [Epub ahead of print]
PMID:
17234809
がんウィルスが感染したがん細胞は、ウィルス抵抗性が弱まる
Ibrahim
F, Rohr J, Jeong WJ, Hesson J, Cerutti H.
Untemplated oligoadenylation promotes degradation of RISC-cleaved
transcripts.
Science. 2006 Dec
22;314(5807):1893.
PMID: 17185594
RISCで切断されたmRNA分子の5'側をアデニル化すると、分解が速く進む
より効果的なRNAiシステムができるかもしれません
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