バイオ研究とバイオ研究者の情報チャンネル
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20100914
siRNA

30970






Experimental therapies: Vectoring siRNA therapeutics into the clinic.
Ferrari M.
Nat Rev Clin Oncol. 2010 Sep;7(9):485-6. No abstract available. PMID: 20798696
レビュー


Targeting cancer cells with nucleic acid aptamers.
Cerchia L, de Franciscis V.
Trends Biotechnol. 2010 Aug 16. [Epub ahead of print]PMID: 20719399
がん治療へのアプタマーの応用


Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery.
Kwok A, Hart SL.
Nanomedicine. 2010 Aug 9. [Epub ahead of print]PMID: 20709624
siRNA導入試薬


RNA-based antiviral immunity.
Ding SW.
Nat Rev Immunol. 2010 Aug 13. [Epub ahead of print]PMID: 20706278
スモールRNAによるウィルス免疫

Image-Guided Breast Tumor Therapy Using a siRNA Nanodrug.
Kumar M, Yigit M, Dai G, Moore A, Medarova Z.
Cancer Res. 2010 Aug 11. [Epub ahead of print]PMID: 20702603
がん治療に使われるsiRNA


The epigenome and the mitochondrion: bioenergetics and the evironment.
Wallace DC.
Genes Dev. 2010 Aug 1;24(15):1571-3.PMID: 20679390
siRNAのスクリーニングで、ミトコンドリアに関する遺伝子を多数発見


Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin.
Ueba H, Brines M, Yamin M, Umemoto T, Ako J, Momomura SI, Cerami A, Kawakami M.
Proc Natl Acad Sci U S A. 2010 Jul 26. [Epub ahead of print]PMID: 20660739
エリスロポエチンに似たペプチド


Involvement of caveolin-1 in fibronectin-induced mouse embryonic stem cell proliferation: Role of FAK, RhoA, PI3K/Akt, and ERK 1/2 pathways.
Park JH, Ryu JM, Han HJ.
J Cell Physiol. 2010 Jul 23. [Epub ahead of print]PMID: 20658539
共沈、阻害剤、siRNAなどでタンパク質間相互作用を解析


22-nucleotide RNAs trigger secondary siRNA biogenesis in plants.
Chen HM, Chen LT, Patel K, Li YH, Baulcombe DC, Wu SH.
Proc Natl Acad Sci U S A. 2010 Jul 19. [Epub ahead of print]PMID: 20643946
miRNAから、22ntのsiRNAが産まれる


Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene and endogenous siRNA biosynthesis.
Yelina NE, Smith LM, Jones AM, Patel K, Kelly KA, Baulcombe DC.
Proc Natl Acad Sci U S A. 2010 Jul 15. [Epub ahead of print]PMID: 20634427
siRNAの産生にかかわる遺伝子群

siRNAs from miRNA sites mediate DNA methylation of target genes.
Chellappan P, Xia J, Zhou X, Gao S, Zhang X, Coutino G, Vazquez F, Zhang W, Jin H.
Nucleic Acids Res. 2010 Jul 9. [Epub ahead of print]PMID: 20621980
長さの異なる2種類のsiRNAが産生されるmiRNAサイト


LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV.
Proc Natl Acad Sci U S A. 2010 Jun 28. [Epub ahead of print]PMID: 20616046
miRNAによって調節されるmiRNA関連タンパク質群


SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B, Pagano M.
Nature. 2010 Jul 1;466(7302):138-142.PMID: 20596027
サイクリンFの機能


Dual recognition of CENP-A nucleosomes is required for centromere assembly.
Carroll CW, Milks KJ, Straight AF.
J Cell Biol. 2010 Jun 21. [Epub ahead of print]PMID: 20566683
セントロメア結合タンパク質の相互作用


Unique functionality of 22-nt miRNAs in triggering RDR6-dependent siRNA biogenesis from target transcripts in Arabidopsis.
Cuperus JT, Carbonell A, Fahlgren N, Garcia-Ruiz H, Burke RT, Takeda A, Sullivan CM, Gilbert SD, Montgomery TA, Carrington JC.
Nat Struct Mol Biol. 2010 Jun 18. [Epub ahead of print]PMID: 20562854
22ntのmiRNAがsiRNAの産生を抑える


Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells.
Rosner M, Siegel N, Fuchs C, Slabina N, Dolznig H, Hengstschlager M.
Nat Protoc. 2010;5(6):1081-95. Epub 2010 May 20.PMID: 20539284
長時間作用するsiRNA

Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila.
Haley B, Foys B, Levine M.
Proc Natl Acad Sci U S A. 2010 Jun 4. [Epub ahead of print]PMID: 20534445
ショウジョウバエにおけるベクターを使ってのRNAi


Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors.
Saayman S, Arbuthnot P, Weinberg MS.
Nucleic Acids Res. 2010 Jun 4. [Epub ahead of print]PMID: 20525791
long-hairpin-RNAの効果


Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells.
Chen AK, Davydenko O, Behlke MA, Tsourkas A.
Nucleic Acids Res. 2010 May 27. [Epub ahead of print]PMID: 20507905
核内に移行する、RNA検出プローブ


Discovery of microRNAs and other small RNAs in solid tumors.
Meiri E, Levy A, Benjamin H, Ben-David M, Cohen L, Dov A, Dromi N, Elyakim E, Yerushalmi N, Zion O, Lithwick-Yanai G, Sitbon E.
Nucleic Acids Res. 2010 May 18. [Epub ahead of print]PMID: 20483914
固形がんの中の新しいスモールRNA


Proper regulation of a sperm-specific cis-nat-siRNA is essential for double fertilization in Arabidopsis.
Ron M, Alandete Saez M, Eshed Williams L, Fletcher JC, McCormick S
Genes Dev. 2010 May 15;24(10):1010-21.PMID: 20478994
生殖細胞に必要なcis-nat-siRNA

Proteomic identification of Drosophila siRNA-associated factors.
Gerbasi VR, Golden DE, Hurtado SB, Sontheimer EJ.
Mol Cell Proteomics. 2010 May 15. [Epub ahead of print]PMID: 20472918
siRNAに結合するタンパク質群

Knockdown of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth.
Ueyama K, Ikeda K, Sato W, Nakasato N, Horie-Inoue K, Takeda S, Inoue S.
Cancer Gene Ther. 2010 May 14. [Epub ahead of print]PMID: 20467453
siRNAでがんを治療


Multi-functional nanoparticles delivering siRNA and doxorubicin overcome drug resistance in cancer.
Chen Y, Bathula SR, Li J, Huang L.
J Biol Chem. 2010 May 11. [Epub ahead of print]PMID: 20460382
多剤耐性がん細胞の治療方法


The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.
Burrows C, Latip NA, Lam SJ, Carpenter L, Sawicka K, Tzolovsky G, Gabra H, Bushell M, Glover DM, Willis AE, Blagden SP.
Nucleic Acids Res. 2010 Apr 29. [Epub ahead of print]PMID: 20430826
細胞分裂にかかわる、RNA結合タンパク質

Cell cycle: dissecting mitosis.
David R.
Nat Rev Mol Cell Biol. 2010 May;11(5):310.PMID: 20419887
細胞分裂の分析、コメント


Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression.
Miniard AC, Middleton LM, Budiman ME, Gerber CA, Driscoll DM.
Nucleic Acids Res. 2010 Apr 12. [Epub ahead of print]PMID: 20385601
ヌクレオリンとセレンタンパク質の結合


GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.
Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V.
Nat Cell Biol. 2010 Apr 11. [Epub ahead of print]PMID: 20383140
脊椎動物のDNA複製因子に相互作用して、複製に必須の、タンパク質

Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.
Bai Y, Li H, Vu GP, Gong H, Umamoto S, Zhou T, Lu S, Liu F.
Proc Natl Acad Sci U S A. 2010 Apr 1. [Epub ahead of print]PMID: 20360564
リボザイムによって、ウィルスの増殖を抑える

The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.
Strapps WR, Pickering V, Muiru GT, Rice J, Orsborn S, Polisky BA, Sachs A, Bartz SR.
Nucleic Acids Res. 2010 Mar 31. [Epub ahead of print]PMID: 20360048
siRNAのガイド配列は、RNAが望ましい


The role of inositol trisphosphate receptors in autophagy in DT40 cells.
Khan MT, Joseph SK.
J Biol Chem. 2010 Mar 22. [Epub ahead of print]PMID: 20308071
ITPレセプターと自食作用

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A.
Nature. 2010 Mar 21. [Epub ahead of print]PMID: 20305636
siRNAでがんを治療するときの、ナノパーティクルの利用

An RNA-mediated silencing pathway utilizes the coordinated synthesis of two distinct populations of siRNA.
Maine EM.
Mol Cell. 2010 Mar 12;37(5):593-5.PMID: 20227363
線虫における2種類のsiRNA


Designing Optimal siRNA Based on Target Site Accessibility.
Hofacker IL, Tafer H.
Methods Mol Biol. 2010;623:137-54.PMID: 20217549
この号にsiRNA特集あり
配列デザインRNAxs


Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery.
Liu Z, Tabakman S, Welsher K, Dai H.
Nano Res. 2009 Feb 1;2(2):85-120.PMID: 20174481
カーボンナノチューブの応用

Advances in Systemic siRNA Delivery.
Leng Q, Woodle MC, Lu PY, Mixson AJ.
Drugs Future. 2009 Sep;34(9):721.PMID: 20161621
siRNAの導入剤


Uridylation of mature miRNAs and siRNAs by the MUT68 nucleotidyltransferase promotes their degradation in Chlamydomonas.
brahim F, Rymarquis LA, Kim EJ, Becker J, Balassa E, Green PJ, Cerutti H.
Proc Natl Acad Sci U S A. 2010 Feb 8. [Epub ahead of print]PMID: 20142471
スモールRNAの分解機構


Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing.
Mok H, Lee SH, Park JW, Park TG.
Nat Mater. 2010 Jan 24. [Epub ahead of print]PMID: 20098433
多量体のsiRNA


Lipid-like materials for low-dose, in vivo gene silencing.
Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, Frank-Kamenetsky M, Yip KN, Alvarez R, Sah DW, de Fougerolles A, Fitzgerald K, Koteliansky V, Akinc A, Langer R, Anderson DG.
Proc Natl Acad Sci U S A. 2010 Jan 11. [Epub ahead of print]PMID: 20080679
肝臓へのsiRNA導入剤の濃度

Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.
Simmer F, Buscaino A, Kos-Braun IC, Kagansky A, Boukaba A, Urano T, Kerr AR, Allshire RC.
EMBO Rep. 2010 Jan 8. [Epub ahead of print]PMID: 20062003
分裂酵母において、GFPに対するsiRNAが、他のsiRNAの産生を誘導している


Small RNAs: Sorting the strands.
Swami M.
Nat Rev Genet. 2010 Jan;11(1):6. No abstract available. PMID: 20050274
レビュー

Reprogramming towards pluripotency requires AID-dependent DNA demethylation.
Bhutani N, Brady JJ, Damian M, Sacco A, Corbel SY, Blau HM.
Nature. 2009 Dec 21. [Epub ahead of print]PMID: 20027182
ノックダウンで、脱メチル化、細胞をリプログラミング






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