Telomere protection by TPP1 is mediated by POT1a and POT1b.
Kibe T, Osawa GA, Keegan CE, de Lange T.
Mol Cell Biol. 2009 Dec 7. [Epub ahead of print]PMID: 19995905
テロメアの保護

Restoration of muscle functionality by genetic suppression of glycogen synthesis in a murine model of Pompe disease.
Douillard-Guilloux G, Raben N, Takikita S, Ferry A, Vignaud A, Guillet-Deniau I, Favier M, Thurberg BL, Roach PJ, Caillaud C, Richard E.
Hum Mol Genet. 2009 Dec 3. [Epub ahead of print]PMID: 19959526
ノックアウトとノックダウンの比較も


Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.
Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D.
EMBO J. 2009 Nov 19.
PMID: 19927127
細胞周期の停止機構


Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells.
Chowdhury F, Na S, Li D, Poh YC, Tanaka TS, Wang F, Wang N.
Nat Mater. 2009 Oct 18.
PMID: 19838182
ES細胞のストレスへの応答


Regulation of proto-oncogene transcription, cell proliferation, and tumorigenesis in mice by PSF protein and a VL30 noncoding RNA.
Wang G, Cui Y, Zhang G, Garen A, Song X.
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16794-8. Epub 2009 Sep 11.
PMID: 19805375
発がん効果のあるRNAをshRNAで抑制


Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells.
Kruhn A, Wang A, Fruehauf JH, Lage H.
Cell Cycle. 2009 Oct 18;8(20).
PMID: 19770582
がん細胞の多剤耐性を緩和


Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation.
Kenworthy R, Lambert D, Yang F, Wang N, Chen Z, Zhu H, Zhu F, Liu C, Li K, Tang H.
Nucleic Acids Res. 2009 Sep 3.
PMID: 19729514
レンチウィルスによるshRNAの発現で、IFN経路が活性化する


Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression.
Xu XM, Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL.
Nat Protoc. 2009;4(9):1338-48. Epub 2009 Aug 27.
PMID: 19713955
複数のshRNAを発現させるベクター


Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.
Johnson N, Cai D, Kennedy RD, Pathania S, Arora M, Li YC, D'Andrea AD, Parvin JD, Shapiro GI.
Mol Cell. 2009 Aug 14;35(3):327-39.
PMID: 19683496
細胞周期の研究にshRNA


Role of human noncoding RNAs in the control of tumorigenesis.
Li L, Feng T, Lian Y, Zhang G, Garen A, Song X.
Proc Natl Acad Sci U S A. 2009 Jul 22.
PMID: 19625619
ヒト由来のncRNAが、がん化を進行させる

Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses OVA-sensitized Allergic Asthma.
Yang CJ, Liu YK, Liu CL, Shen CN, Kuo ML, Su CC, Tseng CP, Yen TC, Shen CR.
Hum Gene Ther. 2009 Jun 23.
PMID: 19548841
shRNAでぜんそくを抑える

PGC-1[alpha] AND PGC-1[beta] regulate mitochondrial density in neurons.
Przemyslaw W, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A.
J Biol Chem. 2009 Jun 19.
PMID: 19542216
ニューロンにおけるミトコンドリアの密度を調節する


Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication.
Sui HY, Zhao GY, Huang JD, Jin DY, Yuen KY, Zheng BJ.
PLoS ONE. 2009 May 22;4(5):e5671.
PMID: 19479060
インフルエンザウィルスの複製を阻害するsiRNA


Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza a virus replication.
Sui HY, Zhao GY, Huang JD, Jin DY, Yuen KY, Zheng BJ.
PLoS ONE. 2009 May 22;4(5):e5671.
PMID: 19479060
ウィルスの増殖を阻害


siRNA vs. shRNA: Similarities and differences.
Rao DD, Vorhies JS, Senzer N, Nemunaitis J.
Adv Drug Deliv Rev. 2009 Apr 20.
PMID: 19389436
レビュー


Lentiviral delivery of short hairpin RNAs.
Manjunath N, Wu H, Subramanya S, Shankar P.
Adv Drug Deliv Rev. 2009 Mar 31.
PMID: 19341774
レンチウィルスベクターのレビュー


Design and validation of siRNAs and shRNAs.
Tilesi F, Fradiani P, Socci V, Willems D, Ascenzioni F.
Curr Opin Mol Ther. 2009 Apr;11(2):156-64.
PMID: 19330721
設計方法、レビュー

MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon TNFalpha treatment.
Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, Prabhakar BS.
J Biol Chem. 2009 Mar 16.
PMID: 19289468
IG20のバリアントをレンチウィルスベクターから発現するshRNAで抑制


Delivery of CD44shRNA/nanoparticles within cancer cells: Perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ mice
.isra S, Hascall VC, De Giovanni C, Markwald RR, Ghatak S.
J Biol Chem. 2009 Feb 26.
PMID: 19246453
がん細胞へのshRNAと薬剤との併用


Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase.
Muftuoglu M, Souza-Pinto NC, Dogan A, Aamann M, Stevnsner T, Rybanska I, Kirkali G, Dizdaroglu M, Bohr VA.
J Biol Chem. 2009 Jan 29.
PMID: 19179336
共沈とshRNAによるノックダウンで、相互作用を証明

A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors.
hattacharyya S, Biou V, Xu W, Schluter O, Malenka RC.
Nat Neurosci. 2009 Feb;12(2):172-81. Epub 2009 Jan 25.
PMID: 19169250
神経細胞にshRNAを導入し発現


Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition.
Li W, Kotoshiba S, Berthet C, Hilton MB, Kaldis P.
Proc Natl Acad Sci U S A. 2009 Jan 7.
PMID: 19129496