shRNA
20081218
1429
transkingdom
RNA Interference (tkRNAi): A Novel Method to Induce Therapeutic Gene
Silencing.
Nguyen TA, Fruehauf JH.
Methods Mol Biol.
2009;514:27-34.
PMID: 19048211
大腸菌を使ったRNAi
Short
hairpin RNA-mediated silencing of PGC-1-related coactivator (PRC) results in a
severe respiratory chain deficiency associated with the proliferation of
aberrant mitochondria.
Vercauteren K, Gleyzer N, Scarpulla RC.
J Biol Chem. 2008 Nov 26.
PMID: 19036724
レンチウィルスのベクター
Inducible
and reversible gene silencing by stable integration of an shRNA-encoding
lentivirus in transgenic rats.
Herold MJ, van den Brandt J, Seibler J, Reichardt HM.
Proc
Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. Epub 2008 Nov 18.
PMID: 19017805
発現調節可能なレンチウィルスのベクター
Gobeil
S, Zhu X, Doillon CJ, Green MR.
A genome-wide shRNA screen identifies GAS1 as a novel melanoma
metastasis suppressor gene.
Genes
Dev. 2008 Nov 1;22(21):2932-40.
PMID: 18981472
細胞の成長を止めるshRNAをスクリーニング
George
RE, Sanda T, Hanna M, Frohling S, Luther W 2nd, Zhang J, Ahn Y, Zhou W, London
WB, McGrady P, Xue L, Zozulya S, Gregor VE, Webb TR, Gray NS, Gilliland DG,
Diller L, Greulich H, Morris SW, Meyerson M, Look AT.
Activating mutations in ALK provide a therapeutic target in
neuroblastoma.
Nature. 2008 Oct
16;455(7215):975-8.
PMID: 18923525
Stern
P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO.
A system for Cre-regulated RNA interference in vivo.
Proc
Natl Acad Sci U S A. 2008 Sep 16;105(37):13895-900. Epub 2008 Sep
8.
PMID: 18779577
vivoに使える発現ベクター
Bauer
M, Kinkl N, Meixner A, Kremmer E, Riemenschneider M, Forstl H, Gasser T, Ueffing
M.
Prevention of interferon-stimulated gene expression using
microRNA-designed hairpins.
Gene Ther.
2008 Aug 14. [Epub ahead of print]
Single treatment with RNAi against prion protein rescues early
neuronal dysfunction and prolongs survival in mice with prion disease.
Proc
Natl Acad Sci U S A. 2008 Jul 22; 105( 29): 10238-43. Epub 2008 Jul
16.
PMID: 18632556
プリオン病の治療
McBride
JL, Boudreau RL, Harper SQ, Staber PD, Monteys AM, Martins I, Gilmore BL,
Burstein H, Peluso RW, Polisky B, Carter BJ, Davidson BL.
Artificial miRNAs mitigate shRNA-mediated toxicity in the
brain: implications for the therapeutic development of RNAi.
Proc
Natl Acad Sci U S A. 2008 Apr 15; 105( 15): 5868-73. Epub 2008 Apr 8.
PMID: 18398004
Hassani
Z, Francois JC, Alfama G, Morvan Dubois G, Paris M, Giovannangeli C, Demeneix
BA.
A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the
mouse brain.
Nucleic Acids
Res. 2007 Apr 10; [Epub ahead of print]
PMID: 17426128
発現ベクターを脳へ投与
Rao
MK, Wilkinson MF.
Tissue-specific and cell type-specific RNA interference in vivo.
Nat Protoc. 2006;1(3):1494-501.
PMID: 17406440
プロモーターを変えれば、組織特異的に発現
Yugawa
T, Handa K, Narisawa-Saito M, Ohno SI, Fujita M, Kiyono T.
Regulation of Notch1 gene expression by p53 in epithelial cells.
Mol Cell Biol. 2007
Mar 12; [Epub ahead of print]
PMID: 17353266
Shukla
V, Coumoul X, Deng CX.
RNAi-based conditional gene knockdown in mice using a U6 promoter driven
vector.
Int J Biol Sci. 2007
Jan 5;3(2):91-9.
PMID: 17304337
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