protein AND (interaction OR binding)
20100915
1058757
A
quantitative targeted proteomics approach to validate predicted microRNA targets
in C. elegans.
Jovanovic M, Reiter L, Picotti P, Lange V, Bogan E, A
Hurschler B, Blenkiron C, J Lehrbach N, C Ding X, Weiss M, P Schrimpf S, A Miska
E, Groshans H, Aebersold R, O Hengartner M.
Nat
Methods. 2010 Sep 12. [Epub ahead of print]PMID: 20835247
miRNAのターゲットをプロテオーム解析
Human
SIRT6 promotes DNA end resection through CtIP deacetylation.
Kaidi A, Weinert BT, Choudhary C, Jackson SP.
Science. 2010 Sep
10;329(5997):1348-53.PMID: 20829486
SIRT6との相互作用タンパク質の活性
Phosphorylation of MLL by ATR is required for execution of
mammalian S-phase checkpoint.
Liu H, Takeda S, Kumar R, Westergard TD, Brown EJ, Pandita TK,
Cheng EH, Hsieh JJ.
Nature. 2010
Sep 5. [Epub ahead of print]PMID: 20818375
S期のチェックポイントに重要な役割を果たすリン酸化
Variable evolutionary signatures at the heart of
enhancers.
Hardison RC.
Nat
Genet. 2010 Sep;42(9):734-5.PMID: 20802475
エンハンサーの特徴
Human
BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded
DNA.
Liu J, Doty T, Gibson B, Heyer WD.
Nat Struct Mol Biol.
2010 Aug 22. [Epub ahead of print]PMID: 20729859
がん遺伝子と修復タンパク質の完全精製
Non-canonical inhibition of DNA damage-dependent
ubiquitination by OTUB1.
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC,
O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T,
Durocher D.
Nature. 2010
Aug 19;466(7309):941-6.PMID: 20725033
2本鎖切断修復がないときの細胞内の反応
CpG
island clusters and pro-epigenetic selection for CpGs in protein-coding exons of
HOX and other transcription factors.
Branciamore S, Chen ZX, Riggs AD, Rodin SN.
Proc
Natl Acad Sci U S A. 2010 Aug 17. [Epub ahead of print]PMID: 20716685
エクソンのCpGアイランド
Quantitative selection of DNA aptamers through microfluidic
selection and high-throughput sequencing.
Cho M, Xiao Y, Nie J, Stewart R, Csordas AT, Oh SS, Thomson
JA, Soh HT.
Proc
Natl Acad Sci U S A. 2010 Aug 12. [Epub ahead of print]PMID: 20705898
アプタマーの選択方法
The
FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced
Checkpoint Response.
Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD.
Mol
Cell. 2010 Jul 30;39(2):259-268.PMID: 20670894
チェックポイントを制御する、遺伝病の遺伝子
Phages
have adapted the same protein fold to fulfill multiple functions in virion
assembly.
Cardarelli L, Pell LG, Neudecker P, Pirani N, Liu A, Baker LA,
Rubinstein JL, Maxwell KL, Davidson AR.
Proc
Natl Acad Sci U S A. 2010 Jul 26. [Epub ahead of print]PMID: 20660769
ファージタンパク質のフォールディング
PED
interacts with Rac1 and regulates cell migration/invasion processes in human
non-small cell lung cancer cells.
Zanca C, Cozzolino F, Quintavalle C, Di Costanzo S,
Ricci-Vitiani L, Santoriello M, Monti M, Pucci P, Condorelli G.
J Cell Physiol. 2010
Oct;225(1):63-72.PMID: 20648624
がん細胞の凝集と浸潤に関与する遺伝子の相互作用
Delivery of molecules into cells using carbon nanoparticles
activated by femtosecond laser pulses.
Chakravarty P, Qian W, El-Sayed MA, Prausnitz MR.
Nat
Nanotechnol. 2010 Jul 18. [Epub ahead of print]PMID: 20639882
レーザーパルスによるエレクトロポレーション
Regulation of myeloid leukaemia by the cell-fate determinant
Musashi.
Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao
C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C,
Oehler VG, Radich JP, Jordan CT, Reya T.
Nature. 2010
Jul 18. [Epub ahead of print]PMID: 20639863
ロイケミアの細胞運命の決定因子
Musashi-2 regulates normal hematopoiesis and promotes
aggressive myeloid leukemia.
Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B,
Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW,
Scholl C, Frohling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley
GQ.
Nat
Med. 2010 Jul 8. [Epub ahead of print]PMID:
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がん細胞を集合させる因子
THE
CRL4CDT2 UBIQUITIN LIGASE MEDIATES THE PROTEOLYSIS OF CDK INHIBITOR XIC1 THROUGH
A DIRECT ASSOCIATION WITH PCNA.
Kim DH, Budhavarapu V, Herrera CR, Nam HW, Kim YS, Yew PR
Mol Cell Biol. 2010 Jul 6. [Epub
ahead of print]PMID: 20606006
ユビキチンライゲースとPCNAとの相互作用
JunB-CBF{beta} signaling is essential to maintain sarcomeric
Z-disc structure and when defective leads to heart failure.
Meder B, Just S, Vogel B, Rudloff J, Gartner L, Dahme T,
Huttner I, Zankl A, Katus HA, Rottbauer W.
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Cell Sci. 2010 Jul 6. [Epub ahead of print]PMID: 20605922
筋肉細胞における、重要な相互作用
Rab6
and myosin II at the cutting edge of membrane fission.
Valente C, Polishchuk R, De Matteis MA.
Nat
Cell Biol. 2010 Jul;12(7):635-638.PMID:
20596045
細胞分裂の際の細胞膜の分裂
Genome-wide association study in alopecia areata implicates
both innate and adaptive immunity.
Petukhova L, Duvic M, Hordinsky M, Norris D, Price V,
Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos
CI, Gregersen PK, Christiano AM.
Nature. 2010
Jul 1;466(7302):113-117.PMID: 20596022
円形脱毛症の研究
Antimicrobial activity of mucosal-associated invariant T
cells.
Le Bourhis L, Martin E, Peguillet I, Guihot A, Froux N, Core
M, Levy E, Dusseaux M, Meyssonnier V, Premel V, Ngo C, Riteau B, Duban L, Robert
D, Rottman M, Soudais C, Lantz O.
Nat
Immunol. 2010 Jun 27. [Epub ahead of print]PMID: 20581831
細菌感染を防御するMAITリンパ球
Regulation of cell motile behavior by crosstalk between cadherin- and
integrin-mediated adhesions.
Borghi N, Lowndes M, Maruthamuthu V, Gardel ML, Nelson WJ.
Proc
Natl Acad Sci U S A. 2010 Jun 21. [Epub ahead of print]PMID: 20566866
コレステロール代謝に関与するsiRNA
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW.
Nature. 2010
Jun 20. [Epub ahead of print]PMID: 20562859
自食作用のプロテオミクス
Ezrin
tunes T-cell activation by controlling Dlg1 and microtubule positioning at the
immunological synapse.
Lasserre R, Charrin S, Cuche C, Danckaert A, Thoulouze MI, de
Chaumont F, Duong T, Perrault N, Varin-Blank N, Olivo-Marin JC,
Etienne-Manneville S, Arpin M, Di Bartolo V, Alcover A.
EMBO
J. 2010 Jun 15. [Epub ahead of print]PMID:
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エズリンと免疫細胞の挙動
Interference with Sin3 function induces epigenetic
reprogramming and differentiation in breast cancer cells.
Farias EF, Petrie K, Leibovitch B, Murtagh J, Chornet MB,
Schenk T, Zelent A, Waxman S.
Proc
Natl Acad Sci U S A. 2010 Jun 14. [Epub ahead of print]PMID: 20547842
タンパク質の重要なドメインを導入することで、タンパク質間相互作用を阻害し、がん細胞を再分化させる
Pgrmc1
(progesterone receptor membrane component 1) associates with EGFR and regulates
erlotinib sensitivity.
Ahmed IS, Rohe HJ, Twist KE, Craven RJ.
J Biol Chem. 2010 Jun 10.
[Epub ahead of print]PMID: 20538600
EGFR結合タンパク質
Bound to
the messenger.
Pastrana E.
Nat
Methods. 2010 Jun;7(6):422-3.PMID: 20524217
RNAとRNA結合タンパク質を同定
Genome-wide kinetics of nucleosome turnover determined by
metabolic labeling of histones.
Deal RB, Henikoff JG, Henikoff S.
Science. 2010 May
28;328(5982):1161-4.PMID: 20508129
ヌクレオゾームの入れ替えスピードを観察
A single amino acid substitution confers enhanced
methylation activity of mammalian Dnmt3b on chromatin DNA.
Shen L, Gao G, Zhang Y, Zhang H, Ye Z, Huang S, Huang J, Kang
J.
Nucleic Acids Res. 2010 May 27. [Epub
ahead of print]PMID: 20507910
メチル化活性を上げる変異
A global protein kinase and phosphatase interaction network
in yeast.
Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, Larsen
B, Lin ZY, Breitkreutz BJ, Stark C, Liu G, Ahn J, Dewar-Darch D, Reguly T, Tang
X, Almeida R, Qin ZS, Pawson T, Gingras AC, Nesvizhskii AI, Tyers M.
Science. 2010 May
21;328(5981):1043-6.PMID: 20489023
酵母のタンパク質間リン酸化ネットワーク
The tumor suppressors p53, p63, and p73 are regulators of
microRNA processing complex.
Boominathan L.
PLoS One. 2010 May 12;5(5):e10615.PMID: 20485546
がん抑制遺伝子変異細胞における、miRNAの発現変化
Structural basis for the function of the Sacchromyces
cerevisiae Gfd1 protein in mRNA nuclear export.
Zheng C, Fasken MB, Marshall NJ, Brockmann C, Rubinson ME,
Wente SR, Corbett AH, Stewart M.
J Biol Chem. 2010 May 12.
[Epub ahead of print]PMID: 20463024
mRNAを核外に出す因子
eEF1A: Thinking outside the ribosome.
Mateyak MK, Kinzy TG.
J Biol Chem. 2010 May 5.
[Epub ahead of print]PMID: 20444696
コメント
A NusE:NusG complex links transcription and
translation.
Burmann BM, Schweimer K, Luo X, Wahl MC, Stitt BL, Gottesman
ME, Rosch P.
Science. 2010 Apr
23;328(5977):501-4.PMID: 20413501
転写因子とリボゾームタンパク質との相互作用
Stoichiometry and architecture of active DNA replication
machinery in Escherichia coli.
Reyes-Lamothe R, Sherratt DJ, Leake MC.
Science. 2010 Apr
23;328(5977):498-501.PMID: 20413500
複製機構のタンパク質群を観察
Migrastatin analogues target fascin to block
tumour metastasis.
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY.
Nature. 2010 Apr 15;464(7291):1062-6.PMID: 20393565
がんの転移を抑える、細胞骨格阻害剤
Cooperative DNA-binding and sequence-recognition
mechanism of aristaless and clawless.
Miyazono KI, Zhi Y, Takamura Y, Nagata K, Saigo K, Kojima T,
Tanokura M.
EMBO J. 2010 Apr 13. [Epub ahead of
print]PMID: 20389279
ホメオドメインタンパク質のDNA認識構造
Quantifying protein-protein interactions in high
throughput using protein domain microarrays.
Kaushansky A, Allen JE, Gordus A, Stiffler MA, Karp ES, Chang
BH, Macbeath G.
Nat Protoc. 2010 Apr;5(4):773-90. Epub 2010 Apr
1.PMID: 20360771
タンパク質アレイで相互作用を見る
How does the Royal Family of Tudor rule the
PIWI-interacting RNA pathway?
Siomi MC, Mannen T, Siomi H.
Genes Dev. 2010 Apr
1;24(7):636-46.PMID: 20360382
Piwiと相互作用するRNAとタンパク質
Multiple precursor proteins bind individual Tat receptor
complexes and are collectively transported.
Ma X, Cline K.
EMBO J. 2010 Mar 25. [Epub ahead of
print]PMID: 20339348
前駆体タンパク質を輸送する仕組み
Minireview: global regulation and dynamics of ribonucleic
Acid.
Keene JD.
Endocrinology. 2010 Apr;151(4):1391-7.PMID: 20332203
RNAの調節機構
The annexin I sequence Gln9-Ala10-Trp11-Phe12 is a core
structure for interaction with the formyl peptide receptor 1.
Movitz C, Brive L, Hellstrand K, Rabiet MJ, Dahlgren C.
J Biol Chem. 2010 Mar 10.
[Epub ahead of print]PMID: 20220135
アネクシンI配列の相互作用
Engineering cis-telomerase RNAs that add telomeric repeats to
themselves.
Qiao F, Goodrich KJ, Cech TR.
Proc
Natl Acad Sci U S A. 2010 Mar 1. [Epub ahead of print]PMID: 20194781
テロメラーゼRNAのテロメア伸長への効果
Combinatorial profiling of chromatin binding modules reveals
multisite discrimination.
Garske AL, Oliver SS, Wagner EK, Musselman CA, Leroy G, Garcia
BA, Kutateladze TG, Denu JM.
Nat Chem Biol. 2010 Feb 28. [Epub ahead
of print]PMID: 20190764
クロマチン結合モジュールの配列と修飾
Antitumor activity of an allosteric inhibitor of
centromere-associated protein-E.
Wood KW, Lad L, Luo L, Qian X, Knight SD, Nevins N, Brejc K,
Sutton D, Gilmartin AG, Chua PR, Desai R, Schauer SP, McNulty DE, Annan RS,
Belmont LD, Garcia C, Lee Y, Diamond MA, Faucette LF, Giardiniere M, Zhang S,
Sun CM, Vidal JD, Lichtsteiner S, Cornwell WD, Greshock JD, Wooster RF, Finer
JT, Copeland RA, Huang PS, Morgans DJ Jr, Dhanak D, Bergnes G, Sakowicz R,
Jackson JR.
Proc
Natl Acad Sci U S A. 2010 Feb 18. [Epub ahead of print]PMID: 20167803
CENP-Eの阻害剤の、抗がん作用
DNA repair by the cryptic endonuclease activity of Mu
transposase.
Choi W, Harshey RM.
Proc
Natl Acad Sci U S A. 2010 Feb 18. [Epub ahead of print]PMID: 20167799
トランスポゾンによるDNA修復
A Thermally Targeted Peptide Inhibitor of Symmetrical Dimethylation
Inhibits Cancer Cell Proliferation.
Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD,
Raucher D.
Peptides. 2010 Feb 15. [Epub ahead of print]PMID: 20167239
タンパク質間相互作用を阻害するペプチドの効果
Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific
26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.
Conine CC, Batista PJ, Gu W, Claycomb JM, Chaves DA, Shirayama
M, Mello CC.
Proc
Natl Acad Sci U S A. 2010 Feb 4. [Epub ahead of print]PMID: 20133686
オスの不妊に関与する、スモールRNA関連タンパク質
Regulation of Alternative Splicing by Histone Modifications.
Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM,
Misteli T.
Science. 2010 Feb 4. [Epub ahead of
print]PMID: 20133523
RNAスプライシングとヒストンの修飾
Identification and analysis of the interaction between Edc3 and Dcp2
in Saccharomyces cerevisiae.
Harigaya Y, Jones BN, Muhlrad D, Gross JD, Parker R.
Mol Cell Biol. 2010 Jan 19. [Epub
ahead of print]PMID: 20086104
mRNAのデキャッピング
HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in
a sequence-independent manner.
Gao G, Walser JC, Beaucher ML, Morciano P, Wesolowska N, Chen
J, Rong YS.
EMBO J. 2010 Jan 7. [Epub ahead of
print]PMID: 20057353
テロメア末端を守るメカニズム
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