バイオ研究とバイオ研究者の情報チャンネル
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peptide
20091228

1842031



Protein C-terminal labeling and biotinylation using synthetic peptide and split-intein.
Volkmann G, Liu XQ.
PLoS One. 2009 Dec 21;4(12):e8381.PMID: 20027230
タンパク質の標識

Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance.
Lu D, Bernstein DA, Satyshur KA, Keck JL.
Proc Natl Acad Sci U S A. 2009 Dec 16. [Epub ahead of print]PMID: 20018747
SSBペプチド


Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries.
Taghibiglou C, Martin HG, Lai TW, Cho T, Prasad S, Kojic L, Lu J, Liu Y, Lo E, Zhang S, Wu JZ, Li YP, Wen YH, Imm JH, Cynader MS, Wang YT.
Nat Med. 2009 Dec;15(12):1399-406. Epub 2009 Nov 22.PMID: 19966780
脳卒中の治療


Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences.
de Felipe P, Luke GA, Brown JD, Ryan MD.
Biotechnol J. 2009 Nov 27. [Epub ahead of print]PMID: 19946875
連なったタンパク質を分離する2Aという配列


CAMP: a useful resource for research on antimicrobial peptides.
Thomas S, Karnik S, Barai RS, Jayaraman VK, Idicula-Thomas S.
Nucleic Acids Res. 2009 Nov 18.
PMID: 19923233
抗菌ペプチドのデータベース

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.
Schellenberger V, Wang CW, Geething NC, Spink BJ, Campbell A, To W, Scholle MD, Yin Y, Yao Y, Bogin O, Cleland JL, Silverman J, Stemmer WP.
Nat Biotechnol. 2009 Nov 15.
PMID: 19915550
タンパク質の体内での半減期を伸ばすペプチド

Direct inhibition of the NOTCH transcription factor complex.
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE.
Nature. 2009 Nov 12;462(7270):182-8.
PMID: 19907488
転写因子複合体形成を阻害し、転写を阻害するペプチド


A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.
Wang B, Primeau TM, Myers N, Rohrs HW, Gross ML, Lybarger L, Hansen TH, Connolly JM.
Science. 2009 Nov 6;326(5954):871-4.
PMID: 19892989
1種類のペプチドに対する免疫を有するマウス


A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency.
Duchardt F, Ruttekolk IR, Verdurmen W, Lortat-Jacob H, Burck J, Hufnagel H, Fischer R, van den Heuvel M, Lowik DW, Vuister GW, Ulrich A, de Waard M, Brock R.
J Biol Chem. 2009 Oct 26. [Epub ahead of print]
PMID: 19858187
ヒト由来のCPP

Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection.
Helenius IT, Krupinski T, Turnbull DW, Gruenbaum Y, Silverman N, Johnson EA, Sporn PH, Sznajder JI, Beitel GJ.
Proc Natl Acad Sci U S A. 2009 Oct 21. [Epub ahead of print]
PMID: 19846771
CO2濃度と免疫


Translocation and endocytosis for cell-penetrating peptides (CPP) internalization.
Jiao CY, Delaroche D, Burlina F, Alves ID, Chassaing G, Sagan S.
J Biol Chem. 2009 Oct 15. [Epub ahead of print]
PMID: 19833724
細胞浸透ペプチド

Hidden dynamic allostery in a PDZ domain.
Petit CM, Zhang J, Sapienza PJ, Fuentes EJ, Lee AL.
Proc Natl Acad Sci U S A. 2009 Oct 14.
PMID: 19828436
動的変化


C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.
Schmidt H, Stonkute A, Juttner R, Koesling D, Friebe A, Rathjen FG.
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16847-52. Epub 2009 Sep 17.
PMID: 19805384
ナトリウム利尿ホルモンペプチドが、神経細胞の分岐を引き起こす

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration.
Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E.
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16157-62. Epub 2009 Sep 2.
PMID: 19805273
ペプチドのC末端ルール


A proteomics approach to discovering natural products and their biosynthetic pathways.
Bumpus SB, Evans BS, Thomas PM, Ntai I, Kelleher NL.
Nat Biotechnol. 2009 Sep 20.
PMID: 19767731
非リボゾーム合成系で合成される機能性ペプチドの探索


Preparation of carbon nanotube bioconjugates for biomedical applications.
Liu Z, Tabakman SM, Chen Z, Dai H.
Nat Protoc. 2009;4(9):1372-82. Epub 2009 Sep 3.
PMID: 19730421
プロトコール

Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues.
Ziegler CG, Brown JW, Schally AV, Erler A, Gebauer L, Treszl A, Young L, Fishman LM, Engel JB, Willenberg HS, Petersenn S, Eisenhofer G, Ehrhart-Bornstein M, Bornstein SR.
Proc Natl Acad Sci U S A. 2009 Aug 27.
PMID: 19717419
ホルモンのレセプターを阻害して、がん細胞の増殖を止めるペプチド

The C-terminal elongation of growth-blocking peptide enhances its biological activity and Micelle binding affinity.
Umetsu Y, Aizawa T, Muto K, Yamamoto H, Kamiya M, Kumaki Y, Mizuguchi M, Demura M, Hayakawa Y, Kawano K.
J Biol Chem. 2009 Aug 26.
PMID: 19710009
昆虫の成長を止めるペプチド


Adenoviral Transfer of Vasoactive Intestinal Peptide (VIP) Gene Inhibits Rat Aortic and Pulmonary Artery Smooth Muscle Cell Proliferation.
St Hilaire RC, Kadowitz PJ, Jeter JR Jr.
Peptides. 2009 Aug 18.
PMID: 19698755
平滑筋細胞の増殖を抑えるペプチド

A C-terminal cationic fragment derived from an arginine-rich peptide exhibits in vitro antibacterial and anti-plasmodial activities governed by its secondary structure properties.
Lesmes LP, Bohorquez MY, Carreno LF, Patarroyo ME, Lozano JM.
Peptides. 2009 Aug 18.
PMID: 19698754
アルギニンリッチペプチドの活性

Adenoviral Transfer of Vasoactive Intestinal Peptide (VIP) Gene Inhibits Rat Aortic and Pulmonary Artery Smooth Muscle Cell Proliferation.
St Hilaire RC, Kadowitz PJ, Jeter JR Jr.
Peptides. 2009 Aug 18.
PMID: 19698755
サイクリックペプチドライブラリーのスクリーニング

In vivo anti-melanoma activities of the Melan-A/MART-1(101-115) T CD4+ cell peptide.
Balasse E, Gatouillat G, Patigny D, Andry MC, Madoulet C.
Vaccine. 2009 Aug 14.
PMID: 19686694
抗がん活性のあるペプチド

DNA-catalyzed sequence-specific hydrolysis of DNA.
Chandra M, Sachdeva A, Silverman SK.
Nat Chem Biol. 2009 Aug 16.
PMID: 19684594
DNAリボザイムのDNA分解活性


Monitoring peptidase activities in complex proteomes by MALDI-TOF mass spectrometry.
Villanueva J, Nazarian A, Lawlor K, Tempst P.
Nat Protoc. 2009;4(8):1167-83. Epub 2009 Jul 23.
PMID: 19617888

Nano-delivery in Airway Diseases: Challenges and Therapeutic Applications.
Roy I, Vij N.
Nanomedicine. 2009 Jul 15.
PMID: 19616124

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.
Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S.
Nat Chem Biol. 2009 Jul 13.
PMID: 19597508


Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
Thompson CH, Olivetti PR, Fuller MD, Freeman CS, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA.
J Biol Chem. 2009 Jul 1.
PMID: 19574231
細胞膜チャネルをふさぐ、ペプチド毒


Designed beta-boomerang antiendotoxic and antimicrobial peptides: Structures and activities in lipopolysaccharide.
Bhunia A, Mohanram H, Domadia PN, Torres J, Bhattacharjya S.
J Biol Chem. 2009 Jun 11.
PMID: 19520860
抗菌ペプチドの構造

Thrombospondin-1 is a transcriptional repression target of PRMT6.
Michaud-Levesque J, Richard S.
J Biol Chem. 2009 Jun 9.
PMID: 19509293
siRNA処理した細胞をマイクロアレイで解析


Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes.
Erturk-Hasdemir D, Broemer M, Leulier F, Lane WS, Paquette N, Hwang D, Kim CH, Stoven S, Meier P, Silverman N.
Proc Natl Acad Sci U S A. 2009 Jun 4.
PMID: 19497884
抗菌ペプチドの発現誘導

Phage-encoded combinatorial chemical libraries based on bicyclic peptides.
Heinis C, Rutherford T, Freund S, Winter G.
Nat Chem Biol. 2009 May 31.
PMID: 19483697
2つのサークル状のペプチドライブラリーをセレクション

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth.
Crombez L, Morris MC, Dufort S, Aldrian-Herrada G, Nguyen Q, Mc Master G, Coll JL, Heitz F, Divita G.
Nucleic Acids Res. 2009 May 29.
PMID: 19483097
siRNAの導入に使う、ペプチドキャリアー





Carter PH, Liu RQ, Foster WR, Tamasi JA, Tebben AJ, Favata M, Staal A, Cvijic ME, French MH, Dell V, Apanovitch D, Lei M, Zhao Q, Cunningham M, Decicco CP, Trzaskos JM, Feyen JH.
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Proc Natl Acad Sci U S A. 2007 Apr 11; [Epub ahead of print]
PMID: 17428923
ホルモンのN末端ペプチドをプローブにして、阻害ペプチドを見つける


Asara JM, Schweitzer MH, Freimark LM, Phillips M, Cantley LC.
Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry.
Science. 2007 Apr 13;316(5822):280-285.
PMID: 17431180
恐竜のプロテオミクス解析


Kanekiyo T, Ban T, Aritake K, Huang ZL, Qu WM, Okazaki I, Mohri I, Murayama S, Ozono K, Taniike M, Goto Y, Urade Y.
Lipocalin-type prostaglandin D synthase/{beta}-trace is a major amyloid {beta}-chaperone in human cerebrospinal fluid.
Proc Natl Acad Sci U S A. 2007 Apr 2; [Epub ahead of print]
PMID: 17404210

凝集するペプチド

Alonso S, Pethe K, Russell DG, Purdy GE.
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy.
Proc Natl Acad Sci U S A. 2007 Mar 26; [Epub ahead of print]
PMID: 17389386


Mazza C, Auphan-Anezin N, Gregoire C, Guimezanes A, Kellenberger C, Roussel A, Kearney A, van der Merwe PA, Schmitt-Verhulst AM, Malissen B.
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
EMBO J. 2007 Mar 15; [Epub ahead of print]
PMID: 17363906


Venkatraman P, Nguyen TT, Sainlos M, Bilsel O, Chitta S, Imperiali B, Stern LJ.
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Nat Chem Biol. 2007 Mar 11; [Epub ahead of print]
PMID: 17351628
蛍光アミノ酸で、抗原ペプチドの挙動を観察


Ichikawa K, Urakami T, Yonezawa S, Miyauchi H, Shimizu K, Asai T, Oku N.
Enhanced desensitization efficacy by liposomal conjugation of a specific antigen.
Int J Pharm. 2006 Dec 16; [Epub ahead of print]
PMID: 17234372


Chen M, Bouvier M.
Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection.
EMBO J. 2007 Mar 1; [Epub ahead of print]
PMID: 17332746
抗原ペプチドの鋳型


Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Heng Qi H, Whetstine JR, Bonni A, Roberts TM, Shi Y.
The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases.
Cell. 2007 Feb 21; [Epub ahead of print]
PMID: 17320160


Burkhard P.
Design of multifunctional peptide nanoparticles for diagnostic applications.
Nanomedicine. 2006 Dec;2(4):283. No abstract available.
PMID: 17292198
バイオ物質を工学の材料としてみる雑誌


Moore DF, Krokhin OV, Beavis RC, Ries M, Robinson C, Goldin E, Brady RO, Wilkins JA, Schiffmann R.
Proteomics of specific treatment-related alterations in Fabry disease: A strategy to identify biological abnormalities.
Proc Natl Acad Sci U S A. 2007 Feb 14; [Epub ahead of print]
PMID: 17301227
遺伝病のプロテオミクス解析


Iwasaki A.
Division of labor by dendritic cells.
Cell. 2007 Feb 9;128(3):435-6.
PMID: 17289563


Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL, Hess P, Qiu C, Buchmann S, Scherz M, Weller T, Fischli W, Clozel M, Jenck F.
Promotion of sleep by targeting the orexin system in rats, dogs and humans.
Nat Med. 2007 Jan 28; [Epub ahead of print]
PMID: 17259994
眠りを引き起こすペプチド


Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalen M, Gerhardt H, Betsholtz C.
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Nature. 2007 Jan 28; [Epub ahead of print]
PMID: 17259973


Edwards RJ, Moran N, Devocelle M, Kiernan A, Meade G, Signac W, Foy M, Park SD, Dunne E, Kenny D, Shields DC.
Bioinformatic discovery of novel bioactive peptides.
Nat Chem Biol. 2007 Feb;3(2):108-112. Epub 2007 Jan 14.
PMID: 17220901

活性ペプチドを見つける

Pal S, St Leger RJ, Wu LP.
Fungal peptide destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster.
J Biol Chem. 2007 Jan 16; [Epub ahead of print]
PMID: 17227774


Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zhang R, Zhang S, Lin L, Chen K, Xie X, Nan F, Young AA, Wang MW.
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice.
Proc Natl Acad Sci U S A. 2007 Jan 9; [Epub ahead of print]
PMID: 17213311

この号に解説あり

Mallick P, Schirle M, Chen SS, Flory MR, Lee H, Martin D, Ranish J, Raught B, Schmitt R, Werner T, Kuster B, Aebersold R.
Computational prediction of proteotypic peptides for quantitative proteomics.
Nat Biotechnol. 2006 Dec 31; [Epub ahead of print]
PMID: 17195840

プロテオミクス解析の際に、いつも出てくるコントロールとなりうるペプチド分子