バイオ研究とバイオ研究者の情報チャンネル
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peptide
20100915

1909505



Structural basis of substrate recognition and specificity in the N-end rule pathway.
Matta-Camacho E, Kozlov G, Li FF, Gehring K.
Nat Struct Mol Biol. 2010 May 12. [Epub ahead of print]PMID: 20835242
タンパク質の寿命を決める、N末ルール

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Bengtson MH, Joazeiro CA.
Nature. 2010 Sep 12. [Epub ahead of print]PMID: 20835226
ストップコドンがなくても翻訳を止める仕組み


Neurotoxicity of Alzheimer's disease Abeta peptides is induced by small changes in the Abeta(42) to Abeta(40) ratio.
Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B.
EMBO J. 2010 Sep 3. [Epub ahead of print]PMID: 20818335
アミロイドペプチドの比率と神経毒性


Gliadin Peptide p31-43 localises to endocytic vesicles and interferes with their maturation.
Barone MV, Nanayakkara M, Paolella G, Maglio M, Vitale V, Troiano R, Ribecco MT, Lania G, Zanzi D, Santagata S, Auricchio R, Troncone R, Auricchio S.
PLoS One. 2010 Aug 18;5(8). pii: e12246.PMID: 20805894
小麦タンパク質、グリアジンペプチドの細胞内での挙動


Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis.
Matsuzaki Y, Ogawa-Ohnishi M, Mori A, Matsubayashi Y.
Science. 2010 Aug 27;329(5995):1065-7.PMID: 20798316
植物の成長ペプチド

An adaptable peptide-based porous material.
Rabone J, Yue YF, Chong SY, Stylianou KC, Bacsa J, Bradshaw D, Darling GR, Berry NG, Khimyak YZ, Ganin AY, Wiper P, Claridge JB, Rosseinsky MJ.
Science. 2010 Aug 27;329(5995):1053-7.PMID: 20798314
ペプチドでできた多孔材料

Adaptor protein is essential for insect cytokine signaling in hemocytes.
Oda Y, Matsumoto H, Kurakake M, Ochiai M, Ohnishi A, Hayakawa Y.
Proc Natl Acad Sci U S A. 2010 Aug 23. [Epub ahead of print]PMID: 20798052
昆虫の成長阻害ペプチド


How the insect immune system interacts with an obligate symbiotic bacterium.
Douglas AE, Bouvaine S, Russell RR.
Proc Biol Sci. 2010 Aug 18. [Epub ahead of print]PMID: 20719775
アブラムシの免疫


Antimicrobial cyclic decapeptides with anticancer activity.
Feliu L, Oliveras G, Cirac AD, Besalu E, Roses C, Colomer R, Bardaji E, Planas M, Puig T.
Peptides. 2010 Aug 10. [Epub ahead of print]PMID: 20708052
抗菌ペプチドの抗がん作用


Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.
Halls ML, Cooper DM.
EMBO J. 2010 Jul 27. [Epub ahead of print]PMID: 20664520
Gタンパク質が作るシグナルゾーム


Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.
Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J.
Proc Natl Acad Sci U S A. 2010 Jul 26. [Epub ahead of print]PMID: 20660724
D-ペプチドの阻害剤


Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis.
Kondo T, Plaza S, Zanet J, Benrabah E, Valenti P, Hashimoto Y, Kobayashi S, Payre F, Kageyama Y.
Science. 2010 Jul 16;329(5989):336-9.PMID: 20647469
昆虫の転写因子を切断する植物のペプチド


Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination.
Van Tendeloo VF, Van de Velde A, Van Driessche A, Cools N, Anguille S, Ladell K, Gostick E, Vermeulen K, Pieters K, Nijs G, Stein B, Smits EL, Schroyens WA, Gadisseur AP, Vrelust I, Jorens PG, Goossens H, de Vries IJ, Price DA, Oji Y, Oka Y, Sugiyama H, Berneman ZN.
Proc Natl Acad Sci U S A. 2010 Jul 14. [Epub ahead of print]PMID: 20631300
樹状細胞ワクチン接種によるがんの治療


The pros and cons of peptide-centric proteomics.
Duncan MW, Aebersold R, Caprioli RM.
Nat Biotechnol. 2010 Jul;28(7):659-64. No abstract available. PMID: 20622832
レビュー

High-throughput engineering and analysis of peptide binding to class II MHC.
Jiang W, Boder ET.
Proc Natl Acad Sci U S A. 2010 Jul 9. [Epub ahead of print]PMID: 20622157
抗原性のハイスループット解析


Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses.
Gras S, Kedzierski L, Valkenburg SA, Laurie K, Liu YC, Denholm JT, Richards MJ, Rimmelzwaan GF, Kelso A, Doherty PC, Turner SJ, Rossjohn J, Kedzierska K.
Proc Natl Acad Sci U S A. 2010 Jun 28. [Epub ahead of print]PMID: 20616031
新型インフルエンザに対する免疫は、1918年のインフルエンザと同じ性質がある


The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor.
Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
Nature. 2010 Jul 1;466(7302):118-122.PMID: 20596023
マウスのオスの性フェロモン、7kDa


Bowels control brain: gut hormones and obesity.
Field BC, Chaudhri OB, Bloom SR.
Nat Rev Endocrinol. 2010 Jun 29. [Epub ahead of print]PMID: 20585346
腸ホルモンの脳への影響

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.
Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M.
Nat Biotechnol. 2010 Jun 27. [Epub ahead of print]PMID: 20581844
WD40ドメインをターゲットとする基質

Umpolung reactivity in amide and peptide synthesis.
Shen B, Makley DM, Johnston JN.
Nature. 2010 Jun 24;465(7301):1027-32.PMID: 20577205
新しいアミド結合の反応過程


Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides, BP100 and pepR.
Alves CS, Melo MN, Franquelim HG, Ferre R, Planas M, Feliu L, Bardaji E, Kowalczyk W, Andreu D, Santos NC, Fernandes MX, Castanho MA.
J Biol Chem. 2010 Jun 21. [Epub ahead of print]PMID: 20566635
抗菌ペプチドの大腸菌への作用


Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta.
Schonrock N, Ke YD, Humphreys D, Staufenbiel M, Ittner LM, Preiss T, Gotz J.
PLoS One. 2010 Jun 11;5(6):e11070.PMID: 20552018
アルツハイマー病では、脳のmiRNAの発現にも異常がある


Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells.
Cuevas-Ramos G, Petit CR, Marcq I, Boury M, Oswald E, Nougayrede JP.
Proc Natl Acad Sci U S A. 2010 Jun 7. [Epub ahead of print]PMID: 20534522
ある種の大腸菌の感染で、DNA損傷が起こる


Staphylococcus aureus Nonribosomal Peptide Secondary Metabolites Regulate Virulence.
Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM, Magarvey NA.
Science. 2010 Jun 3. [Epub ahead of print]PMID: 20522739
ブドウ球菌が2次代謝で作る、毒性のあるペプチド

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain.
Bohlen CJ, Priel A, Zhou S, King D, Siemens J, Julius D.
Cell. 2010 May 28;141(5):834-45.PMID: 20510930
タランチュラの毒の作用


The Leucine Zipper Domains of the Transcription Factors GCN4 and c-Jun Have Ribonuclease Activity.
Nikolaev Y, Deillon C, Hoffmann SR, Bigler L, Friess S, Zenobi R, Pervushin K, Hunziker P, Gutte B.
PLoS One. 2010 May 21;5(5):e10765.PMID: 20505831
ロイシンジッパータンパク質にRNAse活性がある

Native mRNA antisense-accessible sites library for the selection of antisense oligonucleotides, PNAs, and siRNAs.
Fang H, Shen Y, Taylor JS
.RNA. 2010 May 24. [Epub ahead of print]PMID: 20498459
mRNA中のアンチセンスやsiRNAの効きやすい場所


Targeted Nanoparticles that Deliver a Sustained, Specific Release of Paclitaxel to Irradiated Tumors.
Passarella RJ, Spratt DE, van der Ende AE, Phillips JG, Wu H, Sathiyakumar V, Zhou L, Hallahan DE, Harth E, Diaz R.
Cancer Res. 2010 May 18. [Epub ahead of print]PMID: 20484031
放射線照射細胞に輸送するシステム

Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.
Bianchi E, Joyce JG, Miller MD, Finnefrock AC, Liang X, Finotto M, Ingallinella P, McKenna P, Citron M, Ottinger E, Hepler RW, Hrin R, Nahas D, Wu C, Montefiori D, Shiver JW, Pessi A, Kim PS.
Proc Natl Acad Sci U S A. 2010 May 18. [Epub ahead of print]PMID: 20483992
HIV-1に対するペプチドワクチン


Vesicle transport: a new player in APP trafficking.
Owen DJ, Collins BM.
Curr Biol. 2010 May 11;20(9):R413-5.PMID: 20462485
毒性物質の細胞内輸送

Pref-1 Interacts with Fibronectin to Inhibit Adipocyte Differentiation.
Wang Y, Zhao L, Smas C, Sul HS.
Mol Cell Biol. 2010 May 10. [Epub ahead of print]PMID: 20457810
脂肪細胞への分化を止める因子


Zinc ions promote Alzheimer A{beta} aggregation via population shift of polymorphic states.
Miller Y, Ma B, Nussinov R.
Proc Natl Acad Sci U S A. 2010 May 6. [Epub ahead of print]PMID: 20448202
亜鉛イオンで進行する、アルツハイマー病

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.
Ko?mrlj A, Read EL, Qi Y, Allen TM, Altfeld M, Deeks SG, Pereyra F, Carrington M, Walker BD, Chakraborty AK.
Nature. 2010 May 5. [Epub ahead of print]PMID: 20445539
HIVの発病と関係する、HLA型


Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity.
Chanda N, Kattumuri V, Shukla R, Zambre A, Katti K, Upendran A, Kulkarni RR, Kan P, Fent GM, Casteel SW, Smith CJ, Boote E, Robertson JD, Cutler C, Lever JR, Katti KV, Kannan R.
Proc Natl Acad Sci U S A. 2010 Apr 21. [Epub ahead of print]PMID: 20410458
がん特異的なペプチドへの親和性を持つペプチドを用いて、金ナノ粒子をがん細胞へ輸送

C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts.
Boato F, Hendrix S, Huelsenbeck SC, Hofmann F, Grose G, Djalali S, Klimaschewski L, Auer M, Just I, Ahnert-Hilger G, Holtje M.
J Cell Sci. 2010 Apr 20. [Epub ahead of print]PMID: 20406886
C3ペプチドで、傷の治りを早くする


Leukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptides.
Lee YK, Kim KS, Kim JS, Baek JE, Park SI, Jeong HY, Yoon SS, Jung KC, Song HG, Park YS.
Mol Cells. 2010 Apr 12. [Epub ahead of print]PMID: 20396968
細胞特異的抗体を利用したsiRNAの輸送

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM.
Nature. 2010 Apr 15;464(7291):1043-7.PMID: 20393562
遺伝性貧毛症で、変異が見られるWnt阻害タンパク質


Production of an antigenic peptide by insulin-degrading enzyme.
Parmentier N, Stroobant V, Colau D, de Diesbach P, Morel S, Chapiro J, van Endert P, Van den Eynde BJ.
Nat Immunol. 2010 Apr 4. [Epub ahead of print]PMID: 20364150
プロテアゾーム以外の抗原ペプチド産生酵素

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG.
Nature. 2010 Apr 1;464(7289):728-32.PMID: 20360736
眠り病の治療薬候補


Truncated {beta}-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.
Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.
Proc Natl Acad Sci U S A. 2010 Mar 22. [Epub ahead of print]PMID: 20308552
短いβアミロイドペプチド蓄積の影響

MIPs are ancestral ligands for the sex peptide receptor.
Kim YJ, Bartalska K, Audsley N, Yamanaka N, Yapici N, Lee JY, Kim YC, Markovic M, Isaac E, Tanaka Y, Dickson BJ.
Proc Natl Acad Sci U S A. 2010 Mar 22. [Epub ahead of print]PMID: 20308537
昆虫の性ペプチド


Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ.
Nature. 2010 Mar 4;464(7285):104-7.PMID: 20203610
ミトコンドリアからのシグナルで、炎症を引き起こす


Molecular evolution and functional characterization of Drosophila insulin-like peptides.
Gronke S, Clarke DF, Broughton S, Andrews TD, Partridge L.
PLoS Genet. 2010 Feb 26;6(2):e1000857.PMID: 20195512
ショウジョウバエのインシュリン様ペプチド


A g-protein-coupled neuropeptide y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila.
Xu J, Li M, Shen P.
J Neurosci. 2010 Feb 17;30(7):2504-12.PMID: 20164335
神経ペプチドと行動の変化

Enantioselective Sulfonylation Reactions Mediated by a Tetrapeptide Catalyst.
Fiori KW, Puchlopek AL, Miller SJ.
Nat Chem. 2009 Nov 1;1(8):630-634.PMID: 20161563
ペプチドの中のヒスチジンの修飾

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival.
Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY.
Proc Natl Acad Sci U S A. 2010 Feb 16. [Epub ahead of print]PMID: 20160097
細胞浸透ペプチドによる、細胞内輸送


Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens.
Jordan KR, McMahan RH, Kemmler CB, Kappler JW, Slansky JE.
Proc Natl Acad Sci U S A. 2010 Jan 26. [Epub ahead of print]PMID: 20133772
がんに作用するペプチドワクチン


Treatment of Alzheimer's Disease with Anti-Homocysteic Acid Antibody in 3xTg-AD Male Mice.
Hasegawa T, Mikoda N, Kitazawa M, Laferla FM.
PLoS One. 2010 Jan 20;5(1):e8593.PMID: 20098691
アルツハイマー病の抗体治療

An in vitro translation, selection and amplification system for peptide nucleic acids.
Brudno Y, Birnbaum ME, Kleiner RE, Liu DR.
Nat Chem Biol. 2010 Feb;6(2):148-55. Epub 2009 Dec 27.PMID: 20081830
PNAのin vitroでの翻訳、増幅


A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila.
Okamoto N, Yamanaka N, Yagi Y, Nishida Y, Kataoka H, O'Connor MB, Mizoguchi A.
Dev Cell. 2009 Dec;17(6):885-91.PMID: 20059957
インシュリン様ペプチドが、ショウジョウバエを成長させる