バイオ研究とバイオ研究者の情報チャンネル
                   biolohas.jp

 

oligonucleotide 2006年分


156887



Nucleic Acids Symp Ser (Oxf). 2005;(49):331-2.
Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine.
ミスマッチだったときにに特異的に架橋を形成するアンチセンスオリゴ
何かに使えそうな気がしますが。

Gene Ther. 2006 Oct 26
Duchenne muscular dystrophy gene therapy: progress and prospects.
遺伝子治療の一例

Nature. 2006 Oct 12;443(7112):709-12.
Identification of nesfatin-1 as a satiety molecule in the hypothalamus.
食欲をコントロールする遺伝子をアンチセンスモリフォリノオリゴで抑制

Oligonucleotides. 2006 Fall;16(3):253-62
Direct comparison of in vivo antisense activity of ENA oligonucleotides targeting PTP1B mRNA with that of 2'-O-(2-methoxy)ethyl-modified oligonucleotides.
修飾アンチセンスオリゴの比較

Nat Rev Genet. 2006 Sep;7(9):693-702
Evolution of primate gene expression.


Biomed Pharmacother. 2006 Aug 28
An LNA-based loss-of-function assay for micro-RNAs.


Nat Genet. 2006 Aug 13
Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome.
マイクロアレイで、小さな染色体の変異を検出

Nucleosides Nucleotides Nucleic Acids. 2006;25(7):705-17.
Synthesis of poly d(G-C) oligonucleotides.
合成効率の悪い配列の合成

Nucleic Acids Res. 2006 Aug 2;34(13):e94
A matrix of 3,4-diaminobenzophenone for the analysis of oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
新しいマトリックス

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W676-82.

QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences.



Nucleic Acids Res. 2006 Jun 28;34(11):e77.
Ultra fast miniaturized real-time PCR: 40 cycles in less than six minutes.
Neuzil P, Zhang C, Pipper J, Oh S, Zhuo L.
6分で終わるPCR

Cell. 2006 Jun 30;125(7):1309-19
A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli.
Mulcair MD, Schaeffer PM, Oakley AJ, Cross HF, Neylon C, Hill TM, Dixon NE.

Proc Natl Acad Sci U S A. 2006 Jun 22
Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells.
Lei H, Juan AH, Kim MS, Ruddle FH.
Hox転写因子の転写ネットワークをマイクロアレイで解析

Gene Ther. 2006 Jun 8
A multifunctional PEI-based cationic polyplex for enhanced systemic p53-mediated gene therapy.
Moffatt S, Wiehle S, Cristiano RJ.
新しい遺伝子導入試薬


Proc Natl Acad Sci U S A. 2006 Jun 19
Linking DNA-binding proteins to their recognition sequences by using protein microarrays.
Ho SW, Jona G, Chen CT, Johnston M, Snyder M.
あるDNA配列に結合するタンパク質をプロテインアレイで検出する

Nucleic Acids Res. 2006 May 10;34(9):2536-49. Print 2006.
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.
Cogoi S, Xodo LE.
グアニンリッチな4重鎖で、がん遺伝子を抑制する


Curr Opin Mol Ther. 2006 Apr;8(2):122-9.
Nucleic acid aptamers as adjuncts to vaccine development.
Becker KC, Becker RC.
レビュー

Nature. 2006 Mar 23;440(7083):556-60.
RNA-mediated response to heat shock in mammalian cells.
Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E.
ヒートショック反応に関与するRNA分子

Nucleic Acids Res. 2006 Mar 9;34(5):e38.
A novel normalization method for effective removal of systematic variation in microarray data.
Chua SW, Vijayakumar P, Nissom PM, Yam CY, Wong VV, Yang H.
マイクロアレイのデータを補正する方法

Nat Rev Drug Discov. 2006 Feb;5(2):123-32.
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease.
Ng EW, Shima DT, Calias P, Cunningham ET Jr, Guyer DR, Adamis AP.


Gene. 2006 Feb 22
LNA-modified oligonucleotides mediate specific inhibition of microRNA function.
Orom UA, Kauppinen S, Lund AH.
LNAを含むアンチセンスオリゴが、miRNA機能を阻害する

Nucleic Acids Res. 2006 Feb 9;34(3):e22.
BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies.
Fedurco M, Romieu A, Williams S, Lawrence I, Turcatti G.
BTAで5'アミノ化したDNAをガラスプレートに吸着させる。


Nucleic Acids Res. 2006 Jan 30;34(2):734-44.
Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cells.
Napoli S, Negri U, Arcamone F, Capobianco ML, Carbone GM, Catapano CV.
3重鎖剤オリゴが抗がん剤になりうる


Nucleic Acids Res. 2006 Jan 23;34(2):e14.
Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures.
Shi X, Chaires JB.
配列と構造によって異なるリガンドのオリゴ親和性


Nucleic Acids Res. 2006 Jan 18;34(2):451-61.
2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing.
Kalota A, Karabon L, Swider CR, Viazovkina E, Elzagheid M, Damha MJ, Gewirtz AM.
アンチセンスに使える新しい修飾オリゴ

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):921-6.
Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors.
Star A, Tu E, Niemann J, Gabriel JC, Joiner CS, Valcke C.
DNAをラベルしないで検出する方法


Nat Med. 2006 Jan 29
Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology.
Alter J, Lou F, Rabinowitz A, Yin H, Rosenfeld J, Wilton SD, Partridge TA, Lu QL.
アンチセンスのmorpholino oligoの投与によって、Duchenne muscular dystrophy が改善しうるという論文です。




NEWS