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miRNA 20091217


6145

MicroRNAs align with accessible sites in target mRNAs.
Pan W, Xin P, Clawson GA.
J Cell Biochem. 2009 Dec 8. [Epub ahead of print]PMID: 19998415
miRNAが働くサイトを同定

MicroRNA-dependent metamorphosis in hemimetabolan insects.
Gomez-Orte E, Belles X.
Proc Natl Acad Sci U S A. 2009 Dec 4. [Epub ahead of print]PMID: 19966227
ゴキブリを成虫化させないmiRNA

A high-resolution structure of the pre-microRNA nuclear export machinery.
Okada C, Yamashita E, Lee SJ, Shibata S, Katahira J, Nakagawa A, Yoneda Y, Tsukihara T.
Science. 2009 Nov 27;326(5957):1275-9.PMID: 19965479

MicroRNAs couple cell fate and developmental timing in retina.
Decembrini S, Bressan D, Vignali R, Pitto L, Mariotti S, Rainaldi G, Wang X, Evangelista M, Barsacchi G, Cremisi F.
Proc Natl Acad Sci U S A. 2009 Nov 24. [Epub ahead of print]PMID: 19965369


CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.
Castanotto D, Lingeman R, Riggs AD, Rossi JJ.
Proc Natl Acad Sci U S A. 2009 Dec 2. [Epub ahead of print]PMID: 19955415
miRNAの核から細胞質への輸送

Tandem affinity purification of miRNA target mRNAs (TAP-Tar).
Nonne N, Ameyar-Zazoua M, Souidi M, Harel-Bellan A.
Nucleic Acids Res. 2009 Dec 2. [Epub ahead of print]PMID: 19955234
miRNAがターゲットとするmRNAの精製


Distinct mechanisms for microRNA strand selection by Drosophila Argonautes.
Okamura K, Liu N, Lai EC.
Mol Cell. 2009 Nov 13;36(3):431-44.
PMID: 19917251
miRNA因子の結合する順番と、鋳型鎖の認識


The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.
Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG.
Nat Cell Biol. 2009 Nov 8.
PMID: 19898466
miRNAのターゲットの解析

microRNAs at the synapse.
Schratt G.
Nat Rev Neurosci. 2009 Nov 4.
PMID: 19888283
シナプスとmiRNA


Maturation of microRNA is hormonally regulated by a nuclear receptor.
Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama K, Minami Y, O'Malley BW, Kato S.
Mol Cell. 2009 Oct 23;36(2):340-7
PMID: 19854141
ホルモンで調節されるmiRNA

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs.
Chen TS, Lai RC, Lee MM, Choo AB, Lee CN, Lim SK.
Nucleic Acids Res. 2009 Oct 22.
PMID: 19850715
間葉幹細胞のmiRNA


A loop-to-base processing mechanism underlies the biogenesis of plant microRNAs miR319 and miR159.
Bologna NG, Mateos JL, Bresso EG, Palatnik JF.
EMBO J. 2009 Oct 8.
PMID: 19816405
miRNAへのプロセシング

Structural insights into mechanisms of the small RNA methyltransferase HEN1.
Huang Y, Ji L, Huang Q, Vassylyev DG, Chen X, Ma JB.
Nature. 2009 Oct 8;461(7265):823-7.
PMID: 19812675
スモールRNAの3’端塩基を、2'-O-メチル化する酵素の構造


Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling.
Paroo Z, Ye X, Chen S, Liu Q.
Cell. 2009 Oct 2;139(1):112-22.
PMID: 19804757
miRNA複合体のリン酸化過程

Processing of miRNA Precursors.
Kurihara Y, Watanabe Y.
Methods Mol Biol. 2010;592:231-41.
PMID: 19802599
この号に特集あり


Causes and consequences of microRNA dysregulation in cancer.
Croce CM.
Nat Rev Genet. 2009 Oct;10(10):704-14.
PMID: 19763153
発現の原因と結果として起こるmiRNAの発現変化


Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression.
Stoeckius M, Maaskola J, Colombo T, Rahn HP, Friedlander MR, Li N, Chen W, Piano F, Rajewsky N.
Nat Methods. 2009 Sep 6.
PMID: 19734907
線虫の胚におけるスモールRNAの解析

Active turnover modulates mature microRNA activity in Caenorhabditis elegans.
Chatterjee S, Groshans H.
Nature. 2009 Sep 6.
PMID: 19734881


Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
.
Hong X, Hammell M, Ambros V, Cohen SM.
Proc Natl Acad Sci U S A. 2009 Aug 18.
PMID: 19706460
miRNAのターゲットを実際に精製し分類する

Small RNAs: p53 makes microRNAs mature.
Wrighton KH.
Nat Rev Cancer. 2009 Sep;9(9):612. No abstract available.
PMID: 19705527
レビュー

Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP.
Nat Cell Biol. 2009 Aug 23.
PMID: 19701194
miRNAの末端に、mRNAの末端からウリジンを持ってきて、miRNAを活性化させるタンパク質


Structural determinants of miRNAs for RISC loading and slicer-independent unwinding.
Kawamata T, Seitz H, Tomari Y.
Nat Struct Mol Biol. 2009 Aug 16. [Epub ahead of print]
PMID: 19684602

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity.
Gibbings DJ, Ciaudo C, Erhardt M, Voinnet O.
Nat Cell Biol. 2009 Aug 16. [Epub ahead of print]
PMID: 19684575


Rhythmic expression of MicroRNA-26a (mir-26a) regulates the L-type voltage-gated calcium channel {alpha}1C subunit (VGCC{alpha}1C) in chicken cone photoreceptors.
Shi L, Ko ML, Ko GY.
J Biol Chem. 2009 Jul 16.
PMID: 19608742
日周変動するmiRNA

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90. Epub 2009 Jul 13.
PMID: 19597153
非喫煙者の肺がん細胞で発現する、miRNAがアポトーシスを止める


miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.
Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D.
Nature. 2009 Jul 5.
PMID: 19578358
平滑筋の発達に関与するmiRNA

Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells.
Guttilla IK, White BA.
J Biol Chem. 2009 Jul 1.
PMID: 19574223
乳がんに関与するmiRNA

High-resolution profiling and discovery of planarian small RNAs.
Friedlander MR, Adamidi C, Han T, Lebedeva S, Isenbarger TA, Hirst M, Marra M, Nusbaum C, Lee WL, Jenkin JC, Alvarado AS, Kim JK, Rajewsky N.
Proc Natl Acad Sci U S A. 2009 Jun 29.
PMID: 19564616
プラナリアのスモールRNA

Tumors line up for a letdown.
Mendell JT.
Nat Genet. 2009 Jul;41(7):768-9.
PMID: 19557079
コメント、発がんとmiRNA


TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.
Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R.
Nat Cell Biol. 2009 Jun 21.
PMID: 19543271
miRNAが別のmiRNAの発現を調節する

MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.
Pothof J, Verkaik NS, van Ijcken W, Wiemer EA, Ta VT, van der Horst GT, Jaspers NG, van Gent DC, Hoeijmakers JH, Persengiev SP.
EMBO J. 2009 Jun 18.
PMID: 19536137
紫外線照射に反応するmiRNA

A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.
Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA.
Cell. 2009 Jun 12;137(6):1032-46.
PMID: 19524507
乳がんに関係するmiRNA

New hope for a microRNA therapy for liver cancer.
Rossi JJ.
Cell. 2009 Jun 12;137(6):990-2.
PMID: 19524500
miRNAの発現で、肝臓がんを治す


Uniparental expression of PolIV-dependent siRNAs in developing endosperm of Arabidopsis.
Mosher RA, Melnyk CW, Kelly KA, Dunn RM, Studholme DJ, Baulcombe DC.
Nature. 2009 Jun 3.
PMID: 19494814
母性遺伝をする内在性のsiRNA

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.
Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC.
Genes Dev. 2009 Jun 1;23(11):1327-37.
PMID: 19487573
がん細胞で増幅するmiRNA領域


MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice.
Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM, Dimmeler S.
Science. 2009 May 21.
PMID: 19460962
血小板に関与するmiRNA

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.
Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG.
Nature. 2009 May 20.
PMID: 19458619
miRNAを生み出すタンパク質


MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression.
Nam S, Li M, Choi K, Balch C, Kim S, Nephew KP.
Nucleic Acids Res. 2009 May 6.
PMID: 19420067

GeneSet2miRNA: finding the signature of cooperative miRNA activities in the gene lists.
Antonov AV, Dietmann S, Wong P, Lutter D, Mewes HW.
Nucleic Acids Res. 2009 May 6.
PMID: 19420064
機能をウェブで検索

SnapShot: MicroRNAs in Cancer.
Spizzo R, Nicoloso MS, Croce CM, Calin GA.
Cell. 2009 May 1;137(3):586-586.e1. No abstract available.
PMID: 19410551

Allelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repression.
Kim J, Bartel DP.
Nat Biotechnol. 2009 May;27(5):472-477. Epub 2009 Apr 26.
PMID: 19396161
SNIPとmiRNAとの関係


MicroRNAs get a boost.
Heinrichs A.
Nat Rev Mol Cell Biol. 2009 May;10(5):302. No abstract available.
PMID: 19391191
ニューロンで発現するmiRNAクラスター

siRNA vs. shRNA: Similarities and differences.
Rao DD, Vorhies JS, Senzer N, Nemunaitis J.
Adv Drug Deliv Rev. 2009 Apr 20.
PMID: 19389436

A microRNA imparts robustness against environmental fluctuation during development.
Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW.
Cell. 2009 Apr 17;137(2):273-82.
PMID: 19379693

Redefining MicroRNA Targets.
Seitz H.
Curr Biol. 2009 Apr 15.
PMID: 19375315

Fine control: microRNA regulation of adult neurogenesis.
Shen Q, Temple S.
Nat Neurosci. 2009 Apr;12(4):369-70. No abstract available.
PMID: 19322237


Nuclear hormone receptor regulation of microRNAs controls developmental progression.
Bethke A, Fielenbach N, Wang Z, Mangelsdorf DJ, Antebi A.
Science. 2009 Apr 3;324(5923):95-8.
PMID: 19342589
線虫における、miRNAの関与するフィードバック機構

A boost in microRNAs shapes up the neuron.
Muddashetty R, Bassell GJ.
EMBO J. 2009 Mar 18;28(6):617-8. No abstract available.
PMID: 19295499
コメント


The interplay between transcription factors and microRNAs in genome-scale regulatory networks.
Martinez NJ, Walhout AJ.
Bioessays. 2009 Mar 9.
PMID: 19274664
転写因子とmiRNAで形成するネットワーク、レビュー

Pattern formation via small RNA mobility.
Chitwood DH, Nogueira FT, Howell MD, Montgomery TA, Carrington JC, Timmermans MC.
Genes Dev. 2009 Mar 1;23(5):549-54.
PMID: 19270155
発生の際に、細胞間を移動するスモールRNA

TRIM-NHL proteins take on miRNA regulation.
Loedige I, Filipowicz W.
Cell. 2009 Mar 6;136(5):818-20.
PMID: 19269362
miRNAの効き目を決めるタンパク質、コメント

nhl-2 Modulates microRNA activity in Caenorhabditis elegans.
Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V.
Cell. 2009 Mar 6;136(5):926-38.
PMID: 19269369

The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.
Schwamborn JC, Berezikov E, Knoblich JA.
Cell. 2009 Mar 6;136(5):913-25.
PMID: 19269368

MicroRNAs - the micro steering wheel of tumour metastases.
Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA.
Nat Rev Cancer. 2009 Mar 5.
PMID: 19262572
レビュー


Origin, biogenesis, and activity of plant microRNAs.
Voinnet O.
Cell. 2009 Feb 20;136(4):669-87.
PMID: 19239888

Origins and Mechanisms of miRNAs and siRNAs.
Carthew RW, Sontheimer EJ.
Cell. 2009 Feb 20;136(4):642-55.
PMID: 19239886

MicroRNAs and cancer: short RNAs go a long way.
Ventura A, Jacks T.
Cell. 2009 Feb 20;136(4):586-91.
PMID: 19239879


23p53 represses c-Myc through induction of the tumor suppressor miR-145.
Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY.
Proc Natl Acad Sci U S A. 2009 Feb 6.
PMID: 19202062
miRNAによる、がん抑制

The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.
Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF.
Proc Natl Acad Sci U S A. 2009 Feb 5.
PMID: 19196975
miRNAの並びと発生の機序


Biogenesis of small RNAs in animals.
Kim VN, Han J, Siomi MC.
Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-139.
PMID: 19165215
レビュー

MicroRNAs: key regulators of stem cells.
Gangaraju VK, Lin H.
Nat Rev Mol Cell Biol. 2009 Feb;10(2):116-125.
PMID: 19165214
レビュー

A three-dimensional view of the molecular machinery of RNA interference.
Jinek M, Doudna JA.
Nature. 2009 Jan 22;457(7228):405-12.
PMID: 19158786
3次元構造


Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.
Sarasin-Filipowicz M, Krol J, Markiewicz I, Heim MH, Filipowicz W.
Nat Med. 2009 Jan 4.
PMID: 19122656
miRNAの調節と薬剤の効果

DGCR8-dependent microRNA biogenesis is essential for skin development.
Yi R, Pasolli HA, Landthaler M, Hafner M, Ojo T, Sheridan R, Sander C, O'Carroll D, Stoffel M, Tuschl T, Fuchs E.
Proc Natl Acad Sci U S A. 2008 Dec 29.
PMID: 19114655
皮膚の発達とmiRNA

Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs.
Ziegelbauer JM, Sullivan CS, Ganem D.
Nat Genet. 2009 Jan;41(1):130-4. Epub 2008 Dec 21.
PMID: 19098914
miRNAのターゲットをスクリーニング

microRNAs and muscle disorders.
Chen JF, Callis TE, Wang DZ.
J Cell Sci. 2009 Jan 1;122(Pt 1):13-20.
PMID: 19092056
miRNAと筋肉の病気









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