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miRNA 20101004


8666

Small RNAs are on the move.
Chitwood DH, Timmermans MC.
Nature. 2010 Sep 23;467(7314):415-9.PMID: 20864994
コメント


Computational Prediction of MicroRNA Targets.
Wang X.
Methods Mol Biol. 2010;667:283-95.PMID: 20827541
この号に特集あり

MicroRNAs, epigenetics and disease.
Silahtaroglu A, Stenvang J.
Essays Biochem. 2010 Sep 20;48(1):165-85.PMID: 20822493
レビュー


The potential functions of primary microRNAs in target recognition and repression.
Trujillo RD, Yue SB, Tang Y, O'Gorman WE, Chen CZ.
EMBO J. 2010 Aug 31. [Epub ahead of print]PMID: 20808284
70ntのmiRNA前駆体も、発現を抑制する活性がある


Structural basis of microRNA length variety.
Starega-Roslan J, Krol J, Koscianska E, Kozlowski P, Szlachcic WJ, Sobczak K, Krzyzosiak WJ.
Nucleic Acids Res. 2010 Aug 25. [Epub ahead of print]PMID: 20739353
miRNAの長さを質量で測る


Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs.
Schnall-Levin M, Zhao Y, Perrimon N, Berger B.
Proc Natl Acad Sci U S A. 2010 Aug 20. [Epub ahead of print]PMID: 20729470
多様な遺伝子に作用するmiRNA

The microRNA pathway and cancer.

Kwak PB, Iwasaki S, Tomari Y.
Cancer Sci. 2010 Jul 19. [Epub ahead of print]PMID: 20726859
レビュー


Mammalian microRNAs predominantly act to decrease target mRNA levels.
Guo H, Ingolia NT, Weissman JS, Bartel DP.
Nature. 2010 Aug 12;466(7308):835-40.PMID: 20703300
mRNAの量も減らしタンパク質の合成量をさらに下げるmiRNA

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.
Medina PP, Nolde M, Slack FJ.
Nature. 2010 Aug 8. [Epub ahead of print]PMID: 20693987
がん化を引き起こすmiRNA


MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis.
Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, King PD, Weis SM, Cheresh DA.
Nat Med. 2010 Aug 1. [Epub ahead of print]PMID: 20676106
血管新生を引き起こすmiRNA


The widespread regulation of microRNA biogenesis, function and decay.
Krol J, Loedige I, Filipowicz W.
Nat Rev Genet. 2010 Jul 27. [Epub ahead of print]PMID: 20661255
レビュー

MicroRNAs: Genetically Sensitized Worms Reveal New Secrets.
Ambros V.
Curr Biol. 2010 Jul 27;20(14):R598-R600.PMID: 20656201
線虫のmiRNA、レビュー


The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency.
Svoboda P, Flemr M.
EMBO Rep. 2010 Jul 23. [Epub ahead of print]PMID: 20651740
卵母細胞や受精卵におけるsiRNAやmiRNAのはたらき


Quantitative analysis of conditional gene inactivation using rationally designed, tetracycline-controlled miRNAs.
Berger SM, Pesold B, Reber S, Schonig K, Berger AJ, Weidenfeld I, Miao J, Berger MR, Gruss OJ, Bartsch D.
Nucleic Acids Res. 2010 Jul 17. [Epub ahead of print]PMID: 20639530
テトラサイクリンで発現が誘導されるmiRNA


Rationally designed logic integration of regulatory signals in mammalian cells.
Leisner M, Bleris L, Lohmueller J, Xie Z, Benenson Y.
Nat Nanotechnol. 2010 Jul 11. [Epub ahead of print]PMID: 20622866
転写因子の転写の調節


miRNA malfunction causes spinal motor neuron disease.
Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, L Rubin L, Misawa H, Tabin CJ, Brown R Jr, Chen A, Hornstein E.
Proc Natl Acad Sci U S A. 2010 Jun 29. [Epub ahead of print]PMID: 20616011
運動ニューロンの分裂に関与するmiRNA


The Role of MicroRNA in Cardiac Excitability.
Wang Z.
J Cardiovasc Pharmacol. 2010 Jun 24. [Epub ahead of print]PMID: 20588186
神経細胞の興奮に作用するmiRNA

Viral miRNAs: tools for immune evasion.
Boss IW, Renne R.
Curr Opin Microbiol. 2010 Jun 24. [Epub ahead of print]PMID: 20580307
ウィルスの持っているmiRNA


A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.
Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP.
Nature. 2010 Jun 24;465(7301):1033-8.PMID: 20577206
偽遺伝子の発現によって、本当のがん遺伝子の発現が抑えられる


Lineage-specific transcriptional regulation of DICER by MITF in melanocytes.
Levy C, Khaled M, Robinson KC, Veguilla RA, Chen PH, Yokoyama S, Makino E, Lu J, Larue L, Beermann F, Chin L, Bosenberg M, Song JS, Fisher DE.
Cell. 2010 Jun 11;141(6):994-1005.PMID: 20550935
転写調節されるDICER


Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment.
de Planell-Saguer M, Rodicio MC, Mourelatos Z.
Nat Protoc. 2010;5(6):1061-73. Epub 2010 May 20.PMID: 20539282
in sizuでのmiRNAとタンパク質の検出

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction.
D'Alessandra Y, Devanna P, Limana F, Straino S, Di Carlo A, Brambilla PG, Rubino M, Carena MC, Spazzafumo L, De Simone M, Micheli B, Biglioli P, Achilli F, Martelli F, Maggiolini S, Marenzi G, Pompilio G, Capogrossi MC.
Eur Heart J. 2010 Jun 9. [Epub ahead of print]PMID: 20534597
miRNAの分布が、心筋梗塞のバイオマーカーになりうる

Engineered RNA viral synthesis of microRNAs.
Varble A, Chua MA, Perez JT, Manicassamy B, Garcia-Sastre A, Tenoever BR.
Proc Natl Acad Sci U S A. 2010 Jun 7. [Epub ahead of print]PMID: 20534531
ウィルス由来のmiRNA


MicroRNA Networks in Mouse Lung Organogenesis.
Dong J, Jiang G, Asmann YW, Tomaszek S, Jen J, Kislinger T, Wigle DA.
PLoS One. 2010 May 26;5(5):e10854.PMID: 20520778
miRNAと肺の形成

Emerging paradigms of regulated microRNA processing.
Newman MA, Hammond SM.
Genes Dev. 2010 Jun 1;24(11):1086-92.PMID: 20516194
miRNAのプロセッシング


Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.
Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ.
Nat Genet. 2010 May 30. [Epub ahead of print]PMID: 20512147
成体の大きさなどを決める因子

MicroRNA as a new player in the cell cycle.
Chen D, Farwell MA, Zhang B.
J Cell Physiol. 2010 May 19. [Epub ahead of print]PMID: 20506120
細胞周期に関与するmiRNA


Genetic variation in microRNA networks: the implications for cancer research.
Ryan BM, Robles AI, Harris CC.
Nat Rev Cancer. 2010 Jun;10(6):389-402.PMID: 20495573
miRNAとがん研究

The role of small non-coding RNAs in genome stability and chromatin organization.
van Wolfswinkel JC, Ketting RF.
J Cell Sci. 2010 Jun 1;123(Pt 11):1825-39.PMID: 20484663
mcRNAとゲノム安定性


mirTools: microRNA profiling and discovery based on high-throughput sequencing.
Zhu E, Zhao F, Xu G, Hou H, Zhou L, Li X, Sun Z, Wu J.
Nucleic Acids Res. 2010 May 16. [Epub ahead of print]PMID: 20478827
スモールRNAの分類

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis.
Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Naar AM.
Science. 2010 May 13. [Epub ahead of print]PMID: 20466882
miRNAとコレステロールの調節


A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjar N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J.
Nucleic Acids Res. 2010 May 7. [Epub ahead of print]PMID: 20453030
siRNAの7番目の塩基の影響

siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis.
Yu B, Bi L, Zhai J, Agarwal M, Li S, Wu Q, Ding SW, Meyers BC, Vaucheret H, Chen X.
Nucleic Acids Res. 2010 May 6. [Epub ahead of print]PMID: 20448024


The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila.
Bussing I, Yang JS, Lai EC, Groshans H.
EMBO J. 2010 Apr 30. [Epub ahead of print]PMID: 20436454
pri-miRNAを処理するタンパク質


Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by DNA methylation-independent mechanism.
Hutnick LK, Huang X, Loo TC, Ma Z, Fan G.
J Biol Chem. 2010 Apr 19. [Epub ahead of print]PMID: 20404320
メチル化酵素がなくても、レトロトランスポゾンの抑制が起こる

The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing.
Herranz H, Hong X, Perez L, Ferreira A, Olivieri D, Cohen SM, Milan M.
EMBO J. 2010 Apr 16. [Epub ahead of print]PMID: 20400939
ショウジョウバエのDicer-1突然変異体


Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation.

Vohradsky J, Panek J, Vomastek T.
Nucleic Acids Res. 2010 Apr 5. [Epub ahead of print]PMID: 20371515
miRNAによる、mRNAの分解モデル

miRNAs in the Biogenesis of trans-acting siRNAs in Higher Plants.
Allen E, Howell MD.
Semin Cell Dev Biol. 2010 Mar 29. [Epub ahead of print]PMID: 20359543
siRNAから生まれたmiRNA


Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model.
Ma L, Reinhardt F, Pan E, Soutschek J, Bhat B, Marcusson EG, Teruya-Feldstein J, Bell GW, Weinberg RA.
Nat Biotechnol. 2010 Mar 28. [Epub ahead of print]PMID: 20351690
miRNAの抑制で、がんの転移を止める

Modulation of mismatch repair and genomic stability by miR-155.
Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM.
Proc Natl Acad Sci U S A. 2010 Mar 29. [Epub ahead of print]PMID: 20351277
ミスマッチ修復とゲノム安定性を調節するmiRNA


Circulating microRNAs in plasma of patients with gastric cancers.
Tsujiura M, Ichikawa D, Komatsu S, Shiozaki A, Takeshita H, Kosuga T, Konishi H, Morimura R, Deguchi K, Fujiwara H, Okamoto K, Otsuji E.
Br J Cancer. 2010 Mar 16. [Epub ahead of print]PMID: 20234369
血しょう中を循環するmiRNA


Cloning new small RNA sequences.
Tagami Y, Inaba N, Watanabe Y.
Methods Mol Biol. 2010;631:123-38.PMID: 20204873
スモールRNAのクローニング方法

qRT-PCR of Small RNAs.
Varkonyi-Gasic E, Hellens RP.
Methods Mol Biol. 2010;631:109-22.PMID: 20204872
スモールRNAのRT-PCR方法


Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.
Coolen MW, Stirzaker C, Song JZ, Statham AL, Kassir Z, Moreno CS, Young AN, Varma V, Speed TP, Cowley M, Lacaze P, Kaplan W, Robinson MD, Clark SJ.
Nat Cell Biol. 2010 Feb 21. [Epub ahead of print]PMID: 20173741
がん細胞で起こる、長い領域の転写抑制

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.
Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA.
Nat Cell Biol. 2010 Feb 21. [Epub ahead of print]PMID: 20173740
MYCに関与するmiRNA

siRNAs: the hidden face of the small RNA world.

Seitz H.
Curr Biol. 2010 Feb 9;20(3):R108-10.PMID: 20144770
siRNAとmiRNAの機能の重複


siRNAs: The Hidden Face of the Small RNA World.
Seitz H.
Curr Biol. 2010 Feb 9;20(3):R108-R110.PMID: 20144770


Physiological and pathological roles for microRNAs in the immune system.
O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D.
Nat Rev Immunol. 2010 Feb;10(2):111-22.PMID: 20098459
miRNAと免疫、レビュー

Transcriptional control of gene expression by microRNAs.
Khraiwesh B, Arif MA, Seumel GI, Ossowski S, Weigel D, Reski R, Frank W.
Cell. 2010 Jan 8;140(1):111-22.PMID: 20085706
高メチル化サイトのmRNAを切断して、翻訳ではなくて転写を抑制するmiRNA


Opposing microRNA families regulate self-renewal in mouse embryonic stem cells.
Melton C, Judson RL, Blelloch R.
Nature. 2010 Jan 6. [Epub ahead of print]PMID: 20054295
miRNAがES細胞の分化と脱分化に関与


miR-221 overexpression contributes to liver tumorigenesis.
Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A.
Proc Natl Acad Sci U S A. 2009 Dec 15. [Epub ahead of print]PMID: 20018759
がん化に関与するmiRNA








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