バイオ研究とバイオ研究者の情報チャンネル
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antibody
2006年分

756122

Science. 2006 Dec 14Antibody Class Switching Mediated by Yeast Endonuclease-Generated DNA Breaks.
酵母の制限酵素で置き換える

Proc Natl Acad Sci U S A. 2006 Dec 5
Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung.
レジオネラ菌の感染能力が違う変異体

Proc Natl Acad Sci U S A. 2006 Dec 1
Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis.
自己免疫反応

Proc Natl Acad Sci U S A. 2006 Nov 20
Poly(ADP-ribose) (PAR) polymer is a death signal.
Poly(ADP-ribose)そのものが細胞死のシグナルになる

J Biol Chem. 2006 Nov 8
The EGFR tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers: Implications for combination therapy with mab 806.
薬剤と抗体で、EGFRを阻害

Nature. 2006 Oct 26;443(7114):998-1002
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
新聞にも載りましたが、アポトーシスでDNAを分解できないマウスが、リューマチと同じような症状を示す。

Nat Methods. 2006 Nov;3(11):887-9
Targeting and tracing antigens in live cells with fluorescent nanobodies.
抗原を蛍光で追跡

Nat Med. 2006 Oct 15
Interleukin-10 determines viral clearance or persistence in vivo.
IL-10が決定するT細胞の反応

Nucleic Acids Res. 2006 Sep 29
In vitro evolution of single-chain antibodies using mRNA display.
抗体のセレクション

Proc Natl Acad Sci U S A. 2006 Sep 25
Monoclonal antibodies from plants: A new speed record.
植物細胞で、モノクロ抗体を作る

Proc Natl Acad Sci U S A. 2006 Sep 14
A rationally designed agonist antibody fragment that functionally mimics thrombopoietin.
活性のあるペプチドをセレクション

Kubetzko S, Balic E, Waibel R, Zangemeister-Wittke U, Pluckthun A.
PEGylation and multimerization of the Anti-p185-HER-2 single-chain Fv fragment 4D5: Effects on tumor targeting.
J Biol Chem. 2006 Sep 8

Mol Cell. 2006 Sep 1;23(5):749-55
Nuclear Myosin VI Enhances RNA Polymerase II-Dependent Transcription.
核内のミオシンが、転写量を調節、核内構造物がRNAポリメラーゼを動かすか?

Nat Clin Pract Rheumatol. 2006 Aug;2(8):400-1.
Are anti-cyclic citrullinated peptide antibodies pathogenic in rheumatoid arthritis?
特集あり

Proc Natl Acad Sci U S A. 2006 Aug 8
West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody.
西ナイルウィルスを中和するモノクロ抗体

Nat Struct Mol Biol. 2006 Jul 23
Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.
HIVワクチン抗体

Nat Rev Microbiol. 2006 Aug;4(8):588-96.

Aptamers come of age - at last.


Curr Opin Biotechnol. 2006 Jul 10

Applications of antibody array platforms.


Proc Natl Acad Sci U S A. 2006 Jul 5
Breaking the one antibody-one target axiom.
Guo F, Das S, Mueller BM, Barbas CF 3rd, Lerner RA, Sinha SC.
新しい免疫療法

Nat Rev Cancer. 2006 Jul;6(7):559-65.
Immunotoxin therapy of cancer.
Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ.


J Immunol. 2006 Jul 1;177(1):333-40.
Trends in Antibody Sequence Changes during the Somatic Hypermutation Process.
Clark LA, Ganesan S, Papp S, van Vlijmen HW.
抗体の配列の多様性

J Biol Chem. 2006 May 19
Bcl-2 phosphorylation by p38 MAPK: identification of target sites and biologic consequences.
De Chiara G, Marcocci ME, Torcia M, Lucibello M, Rosini P, Bonini P, Higashimoto Y, Damonte G, Armirotti A, Amodei S, Palamara AT, Russo T, Garaci E, Cozzolino F.
リン酸化Bcl-2抗体で解析

Nat Biotechnol. 2006 May 14
A microengraving method for rapid selection of single cells producing antigen-specific antibodies.
Love JC, Ronan JL, Grotenbreg GM, van der Veen AG, Ploegh HL.
マイクロアレイを使って、モノクロ抗体産生細胞を選択する

Nat Chem Biol. 2006 Apr 23
Site-specific PEGylation of native disulfide bonds in therapeutic proteins.
Shaunak S, Godwin A, Choi JW, Balan S, Pedone E, Vijayarangam D, Heidelberger S, Teo I, Zloh M, Brocchini S.
S-S結合をPEGで架橋する。


Nat Methods. 2006 Apr;3(4):295-301.
Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence.
Wehrman TS, von Degenfeld G, Krutzik PO, Nolan GP, Blau HM.
in vivoでのbeta-gal活性を蛍光で測る。

Science. 2006 Mar 24;311(5768):1688-9.
Drug trials. Violent reaction to monoclonal antibody therapy remains a mystery.
Marshall E


Biotechniques. 2006 Feb;40(2):199-208.
Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA.
Bates MK, Zhang G, Sebestyen MG, Neal ZC, Wolff JA, Herweijer H.
発現ベクターを注射して、抗原タンパク質を体内で産生させて、抗体を作る。


Nat Rev Drug Discov. 2006 Mar;5(3):191-5.
Anti-infective monoclonal antibodies: perils and promise of development.
Reichert JM, Dewitz MC.


Nat Rev Drug Discov. 2006 Feb;5(2):97.
Patenting antibodies.
Webber P.


Photochem Photobiol. 2006 Jan 1;
Isothiocyanato Boron Dipyrromethenes - The First BODIPY Analogues of Fluorescein Isothiocyanate (FITC).
Malatesti N, Hudson R, Smith K, Savoie H, Rix K, Welham K, Boyle RW.
新しい蛍光色素






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