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RNA 2006年分

490626

Cell. 2006 Dec 15;127(6):1223-37.
Reconstitution, activities, and structure of the eukaryotic RNA exosome.
遺伝子発現をオフにする仕組みの研究はこれから

Cell. 2006 Dec 15;127(6):1193-207.
Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans.
線虫のsmall RNA

Nature. 2006 Dec 6
A systems biology analysis of the Drosophila phagosome.
1つのオルガネラの中の全タンパク質を同定。プロテオミクス解析をオルガネラごとに分類できる。

Nat Struct Mol Biol. 2006 Dec;13(12):1039-41
RNA interference: unraveling a mystery. レビュー
Nucleic Acids Res. 2006 Dec 5
Insect small nuclear RNA gene promoters evolve rapidly yet retain conserved features involved in determining promoter activity and RNA polymerase specificity.
昆虫のsmall RNAのプロモーター

EMBO J. 2006 Nov 30
ATAB2 is a novel factor in the signalling pathway of light-controlled synthesis of photosystem proteins.
光で転写される遺伝子

Nucleic Acids Res. 2006 Nov 28Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect.
ペプチドを使ってsiRNAを導入

Nat Methods. 2006 Nov;3(11):871.
A protein alternative to RNAi.
ターゲットタンパク質だけを分解させるRNAiに代わる方法

EMBO J. 2006 Nov 16
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors.
RNA polは、鋳型のDNA損傷をどうやって乗り越えるか

Mol Cell Biol. 2006 Nov 13
Individual subunits of the Ssn6-Tup11/12 co-repressor are selectively required for repression of different target genes.
単独でも協調しても働くリプレッサー

Nat Struct Mol Biol. 2006 Nov 12
RNA polymerase III transcribes human microRNAs.
polIIIで転写されるmiRNAもある

Biotechnol Lett. 2006 Nov 8
Establishing efficient siRNA knockdown in mouse embryonic stem cells.
細胞をまいて、4時間でトランスフェクション

Proc Natl Acad Sci U S A. 2006 Nov 3
Small dsRNAs induce transcriptional activation in human cells.
プロモーターに結合して、発現を上昇させるスモールRNA
いろいろ応用できそうです。

Cell. 2006 Nov 3;127(3):565-77
A Two-Hit Trigger for siRNA Biogenesis in Plants.
miRNAが切断されて、siRNAに変化

J Biomed Biotechnol. 2006;2006(4):83757
siRNA Efficiency: Structure or Sequence-That Is the Question.
この号に特集あり

Nature. 2006 Oct 19;443(7113):863-6
An early evolutionary origin for the minor spliceosome.
スプライスゾームの起源

Nucleic Acids Res. 2006 Oct 12
The majority of Escherichia coli mRNAs undergo post-transcriptional modification in exponentially growing cells.
転写後の修飾が、翻訳量を決める因子となるか?

Oncogene. 2006 Oct 9;25(46):6220-7
Implications of micro-RNA profiling for cancer diagnosis.
この号に特集あり

Dev Cell. 2006 Oct;11(4):547-60.
The RNA Helicases p68/p72 and the Noncoding RNA SRA Are Coregulators of MyoD and Skeletal Muscle Differentiation.
IPでncRNAも落ちてきました。

Hum Gene Ther. 2006 Sep 27Synthetic Messenger RNA as a Tool for Gene Therapy.
ベクターではなくmRNAを導入する

Proc Natl Acad Sci U S A. 2006 Sep 28
Defective RNA processing enhances RNA silencing and influences flowering of Arabidopsis.


Proc Natl Acad Sci U S A. 2006 Sep 26
FLASH is required for histone transcription and S-phase progression.


Nat Genet. 2006 Sep 24
Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants.
遺伝子の進化や有用タンパク質開発の際のユニットとして注目される配列です

Science. 2006 Sep 22;313(5794):1788-92.
A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.
リボザイムの進化

Nat Neurosci. 2006 Sep 17
Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1.
アクチンmRNAの局在と細胞の極性

Nature. 2006 Sep 10
Prevalence of off-target effects in Drosophila RNA interference screens.


Methods Mol Biol. 2006;342:87-99
Prediction of microRNA targets.
この号に特集あり

Mol Ther. 2006 Sep 5
Silencing of HIV-1 with RNA Interference: a Multiple shRNA Approach.


Proc Natl Acad Sci U S A. 2006 Sep 1
Chiral-selective aminoacylation of an RNA minihelix: Mechanistic features and chiral suppression.


Nucleic Acids Res. 2006 Aug 31
Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice.
RNAiがうまくいけば、ノックアウトに匹敵する結果を得られる

Nat Clin Pract Neurol. 2006 Jun;2(6):330-8.
Mechanisms of disease: Histone modifications in Huntington's disease.
ハンチントン病の発病モデル

Science. 2006 Aug 25;313(5790):1134-7.
Argonaute slicing is required for heterochromatic silencing and spreading.
siRNAがArgonauteで効く仕組み

Nature. 2006 Aug 16
An RNA gene expressed during cortical development evolved rapidly in humans.
ヒトの脳の発生と遺伝子発現

EMBO Rep. 2006 Aug 11
Formation of GW bodies is a consequence of microRNA genesis.
miRNA作用機構と、mRNA分解機構との関与

Nucleic Acids Res. 2006 Aug 7;34(13):3763-9. Print 2006.
An RNA aptamer that interferes with the DNA binding of the HSF transcription activator.
タンパク質のDNA結合能を阻害するRNAアプタマー

Genes Dev. 2006 Aug 1;20(15):2009-17.
Nucleosome displacement in transcription.


Nat Rev Drug Discov. 2006 Jul;5(7):528-9.
Safety concerns raised over RNA interference.
レビュー

Nat Chem Biol. 2006 Jul 30
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.
もうひとつの遺伝コード

Cell. 2006 Jul 28;126(2):231-5.
Knocking down Disease with siRNAs.
レビュー

Science. 2006 Jul 28;313(5786):518-20.
Transcript-assisted transcriptional proofreading.
転写の際の、塩基の忠実度

Proc Natl Acad Sci U S A. 2006 Jul 24
Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.
CUGリピートが長くなると、スプライシングの異常が起きて、発病するというモデル

Nat Genet. 2006 Jul 23
RNA interference machinery influences the nuclear organization of a chromatin insulator.
RNAiでクロマチンの不活性化を変化させる

Nature. 2006 Jul 20;442(7100):295-8
An RNA-dependent RNA polymerase is required for paramutation in maize.
RNAポリメラーゼが突然変異を引き起こす。果たしてそのメカニズムは。

Science. 2006 Jul 21;313(5785):305-6
MOLECULAR BIOLOGY: A New RNA Dimension to Genome Control.

The discovery of small RNAs, microRNA and siRNA, has revolutionized thinking about the control of gene expression. Now a third new species of small RNA is shown to control gene expression in germline cells.



Methods Mol Biol. 2006;329:233-61.
Gene silencing using RNA interference in embryonic stem cells.
ES細胞のRNAi

Proc Natl Acad Sci U S A. 2006 Jul 10
Yellow flowers generated by expression of the aurone biosynthetic pathway.
Ono E, Fukuchi-Mizutani M, Nakamura N, Fukui Y, Yonekura-Sakakibara K, Yamaguchi M, Nakayama T, Tanaka T, Kusumi T, Tanaka Y.
RNAiで花の色を変える

Curr Biol. 2006 Jul 11;16(13):1344-50.
Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi.
van Haaften G, Romeijn R, Pothof J, Koole W, Mullenders LH, Pastink A, Plasterk RH, Tijsterman M.
RNAiスクリーニングで、放射性感受性に関連する遺伝子を探す

Nature. 2006 Jun 29;441(7097):1172-5.
Structure of the S-adenosylmethionine riboswitch regulatory mRNA element.
Montange RK, Batey RT.
RNAでできた遺伝子調節スイッチ

Oncogene. 2006 Jun 26;25(27):3857-65.
RNA interference-mediated prevention and therapy for hepatocellular carcinoma.
Romano PR, McCallus DE, Pachuk CJ.
RNAiでがんの治療

J Biol Chem. 2006 Jun 23
Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication.
Held DM, Kissel JD, Saran D, Michalowski D, Burke DH.
HIV-1RTを阻害するRNAアプタマー

Nucleic Acids Res. 2006 Jun 21;34(11):3220-30.
RNA helicases and abiotic stress.
Owttrim GW.
レビュー

Med Chem. 2005 Mar;1(2):199-208.
DNA and RNA aptamers as modulators of protein function.
Ulrich H.
アプタマーの設計

Science. 2006 Jun 15
Characterization of the piRNA Complex from Rat Testes.
Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP, Kingston RE.
piRNAとPiwiタンパク質との複合体


EMBO J. 2006 Jun 15
An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation.
Hieb AR, Baran S, Goodrich JA, Kugel JF.
まず8ntを合成すると、mRNAの伸長が始まる

Nature. 2006 Jun 11
Dissecting self-renewal in stem cells with RNA interference.
Ivanova N, Dobrin R, Lu R, Kotenko I, Levorse J, Decoste C, Schafer X, Lun Y, Lemischka IR.
RNAiで幹細胞の分化を調節する


Cell. 2006 Jun 2;125(5):859-72.
A Role for TFIIIC Transcription Factor Complex in Genome Organization.
Noma K, Cam HP, Maraia RJ, Grewal SI.
ゲノム上のタンパク質複合体の局在を見る技術


Cell. 2006 Jun 2;125(5):887-901.
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex.
Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN.
1本鎖のスモールRNA分子が2本鎖になる機構


Nature. 2006 Jun 4
A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA.
生殖細胞の分化に関与するスモールRNA

Nature. 2006 May 31
Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.
Gupta A, Gartner JJ, Sethupathy P, Hatzigeorgiou AG, Fraser NW.
アポトーシスをとめるmiRNA配列が、ウィルスに存在する


Science. 2006 Jun 1
Hierarchical Action and Inhibition of Plant Dicer-Like Proteins in Antiviral Defense.
Deleris A, Gallego-Bartolome J, Bao J, Kasschau KD, Carrington JC, Voinnet O.
アラビドのウィルス防御機構


Nat Genet. 2006 Jun;38 Suppl 1:S25-30.
Viruses and microRNAs.
Cullen BR.
この号にmiRNAの特集あり。レビュー

Proc Natl Acad Sci U S A. 2006 May 26
tRNAHis guanylyltransferase catalyzes a 3'-5' polymerization reaction that is distinct from G-1 addition.
Jackman JE, Phizicky EM.
逆方向に複製する酵素

Nature. 2006 May 25;441(7092):537-41.
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.
Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA.
shRNAの過剰発現で、マウスが致死になる


Nat Immunol. 2006 Jun;7(6):563-7.
Is RNA interference involved in intrinsic antiviral immunity in mammals?
Cullen BR.
レビュー


Mol Cell Biol. 2006 Jun;26(11):4378-85.
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.
Besmer E, Market E, Papavasiliou FN.
塩基の脱アミノ化と転写との関係


Nat Biotechnol. 2006 May 14
Short hairpin RNA-expressing bacteria elicit RNA interference in mammals.
Xiang S, Fruehauf J, Li CJ.
大腸菌にshRNAを組み込むだけで、マウスにRNAiを起こすことができる


Science. 2006 May 12;312(5775):906-10.
RNA recognition and cleavage by a splicing endonuclease.
Xue S, Calvin K, Li H.
RNAスプライシングに関与する酵素

Proc Natl Acad Sci U S A. 2006 May 9
siRNA in human cells selectively localizes to target RNA sites.
Berezhna SY, Supekova L, Supek F, Schultz PG, Deniz AA.
siRNAの局在はターゲットRNAの場所に依存する


Nat Biotechnol. 2006 May;24(5):545-54.
RNA synthetic biology.
Isaacs FJ, Dwyer DJ, Collins JJ.
レビュー

Hum Mol Genet. 2006 Apr 15;15 Suppl 1:R17-29.
Non-coding RNA.
Mattick JS, Makunin IV.
レビュー

Proc Natl Acad Sci U S A. 2006 Apr 24
An internal antisense RNA regulates expression of the photosynthesis gene isiA.
Duhring U, Axmann IM, Hess WR, Wilde A.
シアノバクテリアのアンチセンスをコードする転写産物

Biotechniques. 2006 Apr;Suppl:38-44.
Toward silencing the burden of malaria: progress and prospects for RNAi-based approaches.
Brown AE, Catteruccia F.
Biotechniques. 2006 Apr;Suppl:25-9.
RNAi as a treatment for HIV-1 infection.
Rossi JJ.
この号に特集あり


EMBO J. 2006 Apr 20
The length of the transcript encoded from the Kcnq1ot1 antisense promoter determines the degree of silencing.
Kanduri C, Thakur N, Pandey RR.
長鎖のアンチセンスの効果

J Biol Chem. 2006 Apr 18
Kinetic investigation of E. coli RNA polymerase mutants that influence nucleotide discrimination and transcription fidelity.
Holmes SF, Santangelo TJ, Cunningham CK, Roberts JW, Erie DA.
転写の正確性を決めるRNAポリメラーゼの突然変異

Nucleic Acids Res. 2006 Apr 13;34(7):e52.
An antibody-based microarray assay for small RNA detection.
Hu Z, Zhang A, Storz G, Gottesman S, Leppla SH.
DNARNAハイブリッドを検出する抗体を利用

Bioorg Med Chem Lett. 2006 Apr 5
RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells.
Prakash TP, Kraynack B, Baker BF, Swayze EE, Bhat B.


Proc Natl Acad Sci U S A. 2006 Apr 10
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP, Langer R.
アプタマーの投与方法

Nat Rev Genet. 2006 Apr 11
High-throughput RNAi screening in cultured cells: a user's guide.
Echeverri CJ, Perrimon N.
RNAiのスクリーニング方法

Proc Natl Acad Sci U S A. 2006 Apr 11
Direct evolution of genetic robustness in microRNA.
Borenstein E, Ruppin E.
microRNAの進化

Genes Dev. 2006 Apr 1;20(7):759-771.
Post-transcriptional small RNA pathways in plants: mechanisms and regulations.
Vaucheret H.
植物のsmall RNA。レビュー。

Oligonucleotides. 2006 Spring;16(1):43-57.
Evaluation of Transfection Protocols for Unmodified and Modified Peptide Nucleic Acid (PNA) Oligomers.
Rasmussen FW, Bendifallah N, Zachar V, Shiraishi T, Fink T, Ebbesen P, Nielsen PE, Koppelhus U.
PNAのトランスフェクション

Nature. 2006 Apr 2
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
SCIDの原因

Proc Natl Acad Sci U S A. 2006 Mar 30
A noncoding RNA is a potential marker of cell fate during mammary gland development.
Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, Rosen JM.
PINCの機能

Science. 2006 Mar 31;311(5769):1921-4.
Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT.
Kaleeba JA, Berger EA.
治療のターゲットがはっきりしました。

Nature. 2006 Mar 26
RNAi-mediated gene silencing in non-human primates.
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Rohl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, Maclachlan I.
siRNAのサルへの投与。


Proc Natl Acad Sci U S A. 2006 Mar 27
Suppression of prion protein in livestock by RNA interference.
Golding MC, Long CR, Carmell MA, Hannon GJ, Westhusin ME.
RNAiでプリオンを減らす。

Nat Genet. 2006 Apr;38(4):393.
The underworld of RNA.
Mattick JS.
レビュー

Nucleic Acids Res. 2006 Mar 22;34(6):1669-1675. Print 2006.
Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-{beta}-D-arabinonucleic acid (FANA).
Dowler T, Bergeron D, Tedeschi AL, Paquet L, Ferrari N, Damha MJ.


Science. 2006 Mar 23
RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila.
Wang XH, Aliyari R, Li WX, Li HW, Kim K, Carthew R, Atkinson P, Ding W.

Nat Rev Genet. 2006 Apr;7(4):261-76.
Genetic medicines: treatment strategies for hereditary disorders.
O'connor TP, Crystal RG.
レビュー

Nature. 2006 Mar 16;440(7082):358-62.
Stochastic protein expression in individual cells at the single molecule level.
Cai L, Friedman N, Xie XS.
細胞内の1分子を観察する


Cell. 2006 Mar 10;124(5):877-81.
Micro RNAs in Animal Development.
Plasterk RH.
レビュー

Cell. 2006 Mar 10;124(5):957-71.
RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements.
Grimaud C, Bantignies F, Pal-Bhadra M, Ghana P, Bhadra U, Cavalli G.
ショウジョウバエにおいて、RNAiに関与するタンパク質が、ホメオティック遺伝子がコードするタンパク質と共局在している。つまりRNAiを引き起こす分子機構が、発生に関与している。ビッグニュースです。


Nucleic Acids Res. 2006 Mar 6;34(5):e37.
Control of small inhibitory RNA levels and RNA interference by doxycycline induced activation of a minimal RNA polymerase III promoter.
Amar L, Desclaux M, Faucon-Biguet N, Mallet J, Vogel R.
shRNA発現システム

Nucleic Acids Res. 2006 Mar 3;34(5):e36.
Co-expression of anti-NFkappaB RNA aptamers and siRNAs leads to maximal suppression of NFkappaB activity in mammalian cells.
Chan R, Gilbert M, Thompson KM, Marsh HN, Epstein DM, Pendergrast PS.


Nucleic Acids Res. 2006 Mar 1;34(4):1293-303.
The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase.
Bradrick SS, Walters RW, Gromeier M.
3'UTRの翻訳効率における重要性


J Med Chem. 2006 Mar 9;49(5):1624-34.
Improving RNA Interference in Mammalian Cells by 4'-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2'-O-Alkyl Modifications.
Dande P, Prakash TP, Sioufi N, Gaus H, Jarres R, Berdeja A, Swayze EE, Griffey RH, Bhat B.
修飾siRNAの効果


Genes Dev. 2006 Mar 1;20(5):515-24.
Control of translation and mRNA degradation by miRNAs and siRNAs.
Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R.
miRNAとsiRNAによる、mRNA分解機構モデル

Br J Cancer. 2006 Feb 21
MicroRNAs in cell proliferation, cell death, and tumorigenesis.
Hwang HW, Mendell JT.
microRNAのレビュー

Nucleic Acids Res. 2006 Feb 25;34(4):e33.
The use of biotin tagging in Saccharomyces cerevisiae improves the sensitivity of chromatin immunoprecipitation.
van Werven FJ, Timmers HT.
タンパク質をビオチン化することにより、タンパク質に関与するクロマチンを沈降させることができる


J Biol Chem. 2006 Feb 23
Nucleotide excision-repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein.
Bampi C, Bibillo A, Wendler M, Divita G, Gorelick RJ, Le Grice SF, Darlix JL
HIV-1のRTとNCによって、DNAの塩基の付加、不完全な修復が起こる。

Nat Methods. 2006 Mar;3(3):199-204.
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets.
Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y, Baskerville S, Maksimova E, Robinson K, Karpilow J, Marshall WS, Khvorova A.
アンチセンス鎖の5'側と相同性のある3'UTRをもつ遺伝子が、off-targetを受ける。


Proc Natl Acad Sci U S A. 2006 Feb 13
The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components.
Kotaja N, Bhattacharyya SN, Jaskiewicz L, Kimmins S, Parvinen M, Filipowicz W, Sassone-Corsi P
生殖細胞中のクロマチド体の中身

Proc Natl Acad Sci U S A. 2006 Feb 13
A large family of ancient repeat elements in the human genome is under strong selection.
Kamal M, Xie X, Lander ES.
タンパク質をコードしない繰り返し配列の進化


Nucleic Acids Res. 2006 Feb 2;34(3):773-84.
HelF, a putative RNA helicase acts as a nuclear suppressor of RNAi but not antisense mediated gene silencing.
Popova B, Kuhlmann M, Hinas A, Soderbom F, Nellen W.
HelF遺伝子をつぶすと、RNAiの効率が上がる。


J Biol Chem. 2006 Feb 8
RNA aptamers targeting the cell death inhibitor CED-9 induce cell kiling in C. elegans.
Yang C, Yan N, Parrish J, Wang X, Shi Y, Xue D.
細胞死を引き起こすRNAアプタマー

Biomol Eng. 2006 Feb 6
RNA interference in cancer.
Gartel AL, Kandel ES.


Cancer Lett. 2006 Feb 8;232(2):243-54.
Chemosensitization of bladder cancer cells by survivin-directed antisense oligodeoxynucleotides and siRNA.
Fuessel S, Herrmann J, Ning S, Kotzsch M, Kraemer K, Schmidt U, Hakenberg OW, Wirth MP, Meye A.
オリゴでサバイビンを抑制して、薬剤感受性を変化させるという論文です。


Proc Natl Acad Sci U S A. 2006 Feb 1
Dicer function is essential for lung epithelium morphogenesis.
Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X.
RNAiに関与するDicer欠損の表現型


Proc Natl Acad Sci U S A. 2006 Feb 6
SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase.
Shiu PK, Zickler D, Raju NB, Ruprich-Robert G, Metzenberg RL.
減数分裂の際に、すべての遺伝子の発現を一時的に抑える仕組み。


Pharm Res. 2006 Feb 10
Gene Expression Profiles in Mouse Lung Tissue after Administration of Two Cationic Polymers Used for Nonviral Gene Delivery.
Regnstrom K, Ragnarsson EG, Fryknas M, Koping-Hoggard M, Artursson P.
ポリエチレンイミンとキトサンを使ったDDS法の比較。


Ann Biomed Eng. 2006 Feb 7;:1-12
Nanostructured Probes for RNA Detection in Living Cells.
Santangelo P, Nitin N, Bao G.
生細胞で、RNA分子の細胞内局在を可視化する技術に関するレビューです。


Nat Genet. 2006 Feb;38(2):138-9.
Defense and counterdefense in the plant world.
Waterhouse PM.
RNAi-likeなシステムで、ウィルスからの防御機構が植物にはあるというレビューです。

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