バイオ研究とバイオ研究者の情報チャンネル
                   biolohas.jp

 

RNA 20080804

547522



Powers ET, Balch WE.
Costly mistakes: translational infidelity and protein homeostasis.
Cell. 2008 Jul 25;134(2):204-6.
A small molecule enhances RNA interference and promotes microRNA processing.
Nat Biotechnol. 2008 Jul 20. [Epub ahead of print]
PMID: 18641635
低分子エノクサシンが、RNAiを促進する

Sudarsan N, Lee ER, Weinberg Z, Moy RH, Kim JN, Link KH, Breaker RR.
Riboswitches in eubacteria sense the second messenger cyclic di-GMP.
Science. 2008 Jul 18;321(5887):411-3.
PMID: 18635805
バクテリアの調節に関与するdi-ヌクレオチド

Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermueller J, Hofacker IL, Bell I, Cheung E, Drenkow J, Dumais E, Patel S, Helt G, Ganesh M, Ghosh S, Piccolboni A, Sementchenko V, Tammana H, Gingeras TR.
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription.
Science. 2007 May 17; [Epub ahead of print]
PMID: 17510325
自分の興味のある遺伝子近傍のスモールRNAの発現を調べてみることも面白そうです。


Lim AK, Kai T.
Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster.
Proc Natl Acad Sci U S A. 2007 Apr 11; [Epub ahead of print]
PMID: 17428915
生殖細胞のオルガネラの機能

O'donnell KA, Boeke JD.
Mighty Piwis Defend the Germline against Genome Intruders.
Cell. 2007 Apr 6;129(1):37-44.
PMID: 17418784

レビュー

Amarzguioui M, Lundberg P, Cantin E, Hagstrom J, Behlke MA, Rossi JJ.
Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.
Nat Protoc. 2006;1(2):508-17.
PMID: 17406276
新しいsiRNAの設計と実験方法


Koizumi K, Higashida H, Yoo S, Islam MS, Ivanov AI, Guo V, Pozzi P, Yu SH, Rovescalli AC, Tang D, Nirenberg M.
RNA interference screen to identify genes required for Drosophila embryonic nervous system development.
Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5626-31. Epub 2007 Mar 21.
PMID: 17376868


Shi H, Fan X, Sevilimedu A, Lis JT.
RNA aptamers directed to discrete functional sites on a single protein structural domain.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3742-6. Epub 2007 Feb 28.
PMID: 17360423


Choudhary S, Lee HC, Maiti M, He Q, Cheng P, Liu Q, Liu Y.
A double-stranded RNA response program important for RNAi efficiency.
Mol Cell Biol. 2007 Mar 19; [Epub ahead of print]
PMID: 17371837


Miska EA, Ahringer J.
RNA interference has second helpings.
Nat Biotechnol. 2007 Mar;25(3):302-3. No abstract available.
PMID: 17344882


Typas A, Barembruch C, Possling A, Hengge R.
Stationary phase reorganisation of the Escherichia coli transcription machinery by Crl protein, a fine-tuner of sigma(s) activity and levels.
EMBO J. 2007 Mar 1; [Epub ahead of print]
PMID: 17332743
定常期では、シグマ因子を変えて、遺伝子発現をダイナミックに変化させる


Spada F, Haemmer A, Kuch D, Rothbauer U, Schermelleh L, Kremmer E, Carell T, Langst G, Leonhardt H.
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.
J Cell Biol. 2007 Feb 20; [Epub ahead of print]
PMID: 17312023
PCNAを必要としないDNAメチル化

Rossi JJ.
Transcriptional activation by small RNA duplexes.
Nat Chem Biol. 2007 Mar;3(3):136-7. No abstract available.
PMID: 17301798


Kim DH, Rossi JJ.
Strategies for silencing human disease using RNA interference.
Nat Rev Genet. 2007 Mar;8(3):173-84.
PMID: 17304245


Musatov S, Chen W, Pfaff DW, Mobbs CV, Yang XJ, Clegg DJ, Kaplitt MG, Ogawa S.
Silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.
Proc Natl Acad Sci U S A. 2007 Feb 6; [Epub ahead of print]
PMID: 17284595
アデノウィルスベクターでsiRNAを発現し、メタボリックシンドロームマウスを作る


Irion U, St Johnston D.
bicoid RNA localization requires specific binding of an endosomal sorting complex.
Nature. 2007 Feb 1;445(7127):554-8.
PMID: 17268469
bicoidのmRNAに結合し、局在を決めるたんぱく質


Taghbalout A, Rothfield L.
RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton.
Proc Natl Acad Sci U S A. 2007 Jan 22; [Epub ahead of print]
PMID: 17242352
大腸菌では、RNA分解体が、細胞骨格を形作る


Ma HT, On KF, Tsang YH, Poon RY.
An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells.
Nucleic Acids Res. 2007 Jan 18; [Epub ahead of print]
PMID: 17234679
ターゲット遺伝子を発現誘導させ、shRNAを発現するベクター

Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, Gullans SR.
Molecular markers of early Parkinson's disease based on gene expression in blood.
Proc Natl Acad Sci U S A. 2007 Jan 10; [Epub ahead of print]
PMID: 17215369

パーキンソン病を判定できる遺伝子の発現変化

Wahle E.
Wrong PH for RNA degradation.
Nat Struct Mol Biol. 2007 Jan;14(1):5-7. No abstract available.
PMID: 17203066
取り扱いの注意

Tanaka M, Chock PB, Stadtman ER.
Oxidized messenger RNA induces translation errors.
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):66-71. Epub 2006 Dec 26.
PMID: 17190801
RNAの損傷が細胞へのどんな影響があるのか、興味深いです。

Szutorisz H, Georgiou A, Tora L, Dillon N.
The proteasome restricts permissive transcription at tissue-specific gene Loci in embryonic stem cells.
Cell. 2006 Dec 29;127(7):1375-88.
PMID: 17190601
RNAiの利用方法


NEWS