バイオ研究とバイオ研究者の情報チャンネル
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20080729

DNA

975324





D'Ambrosio C, Kelly G, Shirahige K, Uhlmann F.
Condensin-Dependent rDNA Decatenation Introduces a Temporal Pattern to Chromosome Segregation.
Curr Biol. 2008 Jul 15. [Epub ahead of print]
PMID: 18635352
染色体分離のモデル

Cohan FM, Perry EB.
A systematics for discovering the fundamental units of bacterial diversity.
Curr Biol. 2007 May 15;17(10):R373-86.
PMID: 17502094
配列クラスターに注目


Storici F, Bebenek K, Kunkel TA, Gordenin DA, Resnick MA.
RNA-templated DNA repair.
Nature. 2007 Apr 11; [Epub ahead of print]
PMID: 17429354

RNAを鋳型にして相同組み換え修復が起こりうる

Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.
Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair.
Cell. 2007 Apr 3; [Epub ahead of print]
PMID: 17412408
遺伝病原因遺伝子が次々と明らかに


Kanno SI, Kuzuoka H, Sasao S, Hong Z, Lan L, Nakajima S, Yasui A.
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
EMBO J. 2007 Mar 29; [Epub ahead of print]
PMID: 17396150


Albert I, Mavrich TN, Tomsho LP, Qi J, Zanton SJ, Schuster SC, Pugh BF.
Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome.
Nature. 2007 Mar 29;446(7135):572-6.
PMID: 17392789


Gustafsdottir SM, Schlingemann J, Rada-Iglesias A, Schallmeiner E, Kamali-Moghaddam M, Wadelius C, Landegren U.
In vitro analysis of DNA-protein interactions by proximity ligation.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3067-72. Epub 2007 Feb 20.
PMID: 17360610


Pregibon DC, Toner M, Doyle PS.
Multifunctional encoded particles for high-throughput biomolecule analysis.
Science. 2007 Mar 9;315(5817):1393-6.
PMID: 17347435
生物学が、工学に近づいている段階だと思います

Brown KD, Robertson KD.
DNMT1 knockout delivers a strong blow to genome stability and cell viability.
Nat Genet. 2007 Mar;39(3):289-90.
PMID: 17325677
哺乳類でも、DNAメチル化はゲノム安定性に関与する


Garner EC, Campbell CS, Weibel DB, Mullins RD.
Reconstitution of DNA segregation driven by assembly of a prokaryotic actin homolog.
Science. 2007 Mar 2;315(5816):1270-4.
PMID: 17332412
DNAを動かすアクチンホモログ


Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ.
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.
Nature. 2007 Feb 21; [Epub ahead of print]
PMID: 17314980
実験をしないでも論文がかける時代に。既知の論文のデータをまとめると、新しい発見がある

Xenariou S, Griesenbach U, Liang HD, Zhu J, Farley R, Somerton L, Singh C, Jeffery PK, Ferrari S, Scheule RK, Cheng SH, Geddes DM, Blomley M, Alton EW.
Use of ultrasound to enhance nonviral lung gene transfer in vivo.
Gene Ther. 2007 Feb 15; [Epub ahead of print]
PMID: 17301842
超音波を使って遺伝子導入が上昇


Rai K, Chidester S, Zavala CV, Manos EJ, James SR, Karpf AR, Jones DA, Cairns BR.
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish.
Genes Dev. 2007 Feb 1;21(3):261-6.
PMID: 17289917
モルフォリノオリゴで表現型に変化


Driscoll R, Hudson A, Jackson SP.
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56.
Science. 2007 Feb 2;315(5812):649-52.
PMID: 17272722
Han J, Zhou H, Horazdovsky B, Zhang K, Xu RM, Zhang Z.
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.
Science. 2007 Feb 2;315(5812):653-5.
PMID: 17272723
新しいヒストンアセチル化酵素の欠損で、突然変異がおきやすくなる。ヒトホモログと病気との関連は。

Delaval K, Govin J, Cerqueira F, Rousseaux S, Khochbin S, Feil R.
Differential histone modifications mark mouse imprinting control regions during spermatogenesis.
EMBO J. 2007 Jan 25; [Epub ahead of print]
PMID: 17255950
DNAのメチル化パターンと、ヒストンのアセチル化パターン


Benetti R, Garcia-Cao M, Blasco MA.
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres.
Nat Genet. 2007 Jan 21; [Epub ahead of print]
PMID: 17237781
テロメアの異常で、ヒストンの状態が変わり、ヘテロクロマチンの状態も変わる


Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O.
Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.
EMBO J. 2007 Jan 24;26(2):412-23.
PMID: 17245431
HIV-1の転写を抑える因子


Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th.
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Proc Natl Acad Sci U S A. 2007 Jan 16; [Epub ahead of print]
PMID: 17227866
ウィルス感染を防ぐ遺伝子


Doyle M, Fookes M, Ivens A, Mangan MW, Wain J, Dorman CJ.
An H-NS-like stealth protein aids horizontal DNA transmission in bacteria.
Science. 2007 Jan 12;315(5809):251-2.
PMID: 17218529

プラスミドの移動をスムーズにさせるたんぱく質

Okuyama M, Laman H, Kingsbury SR, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL.
Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells.
Nat Methods. 2007 Jan 14; [Epub ahead of print]
PMID: 17220893

細胞内に取り込まれやすいペプチド分子の形

Pikaard C, Pontes O.
Heterochromatin: condense or excise.
Nat Cell Biol. 2007 Jan;9(1):19-20.
PMID: 17199128



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